Gene ML1158
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE ACETYL-CoA ACETYLTRANSFERASE FADA4 (ACETOACETYL-CoA THIOLASE) |
| Comments | ML1158, len: 393 aa. Probable fadA4, acetyl-CoA C-acetyltransferase (EC 2.3.1.9). Identical to the previously sequenced Mycobacterium leprae probable acetyl-CoA acetyltransferase SW:THIL_MYCLE (P46707) (393 aa), Fasta scores: E(): 0, 100.0% identity in 393 aa overlap. Also highly similar to many others including: Mycobacterium tuberculosis (FadA4) Rv1323 SW:THIL_MYCTU (Q10629) (389 aa), Fasta scores: E(): 0, 86.9% identity in 388 aa overlap and acetyl-CoA acetyltransferases from Alcaligenes eutrophus SW:THIL_ALCEU (P14611) (393 aa), Fasta scores: E(): 0, 50.4% identity in 389 aa overlap. Also similar to ML2162 from M. leprae. Contains Pfam match to entry PF00108 thiolase, Thiolase. Contains PS00098 Thiolases acyl-enzyme intermediate signature. Contains PS00099 Thiolases active site. Contains PS00737 Thiolases signature 2. |
| Functional category | Lipid metabolism |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1352915 | 1354096 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1158|fadA4
MTTSVIVTGARTPIGKLMGSLKDFSASDLGAITIAAALKKANVAPSIVQYVIIGQVLTAGAGQMPARQAAVAAGIGWDVPALTINKMCLSGLDAIALADQLIRAGEFDVVVAGGQESMTKAPHLLMDSRSGYKYGDVTIVDHLAYDGLHDVFTNQPMGALTEQRNDVEKFTRQEQDEFAARSHQKAAAAWKDGVFADEVVPVSIPQSKGDSLQFTEDEGIRANTSAESLAGLKPAFRCGGTITPGSASQISDGAATVVVMNKEKAQQLGLTWLVEIGAHGVVAGPDSTLQSQPANAIKKAVDREGISVEQLDVVEINEAFAAVALASARELGIAPELVNVNGGAIAVGHPLGMSGARITLHVALELARRGSGYGVAALCGAGGQGDALILRAV
Bibliography
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