Gene ML1182c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namePPE
Gene length1266 bp
IdentifierML1182c
Location 1381007 bp
Protein summary information
Molecular mass43119.6 Da
Isoelectric point4.17
Protein length422 amino acids
Structural information
PFAMPF00823
Orthologs
M. tuberculosis H37RvRv1196
Cross-references
UniProtQ7AQ89
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPPE-family protein
CommentsML1182c, len: 421 aa. Member of the PPE protein family. Identical to the previously sequenced Mycobacterium leprae putative PPE protein TR:Q9Z5K0 (EMBL:AL049191) (421 aa), Fasta scores: E(): 0, 100.0% identity in 421 aa overlap. Also highly similar to many members of the Mycobacterium tuberculosis PPE-family of proteins e.g. O05298 Rv1196 (391 aa), fasta scores: E(): 3e-23, (41.135% identity in 423 aa overlap) and Rv2892c SW:YS92_MYCTU (Q10813) (408 aa), Fasta scores: E(): 1.2e-25, 34.0% identity in 429 aa overlap. Also similar to ML1054 a possible pseudogene similar to M. tuberculosis Rv1196. Contains Pfam match to entry PF00823 PPE, PPE family.
Functional categoryPe/ppe
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS13810071382272-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1182c|PPE
MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKELTAAAQGLQSAVEALLTTFEGESAAALAERVTPYEKWLTQNAASAELTATQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKEAEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEEVVEEVVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVATPQTAVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSPARVAVATESESAPLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG
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