Gene ML1183c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namePE6
Gene length300 bp
IdentifierML1183c
Location 1382329 bp
Protein summary information
Molecular mass10117.0 Da
Isoelectric point4.5
Protein length100 amino acids
Orthologues
M. tuberculosisRv1195
Cross-references
UniProtQ49943
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPE FAMILY PROTEIN
CommentsML1183c, len: 99 aa. Member of Mycobacteria PE family. Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49943 (EMBL:AL049191) (99 aa), Fasta scores: E(): 0, 100.0% identity in 99 aa overlap. Also highly similar to many Mycobacterium tuberculosis PE family proteins e.g. TR:O05297 (EMBL:Z93777) Rv1195 (99 aa), Fasta scores: E(): 1.3e-12, 48.9% identity in 92 aa overlap and the N-terminus of several PGRS-family proteins also from M. tuberculosis e.g. Rv0742 TR:O53805 (EMBL:AL021958) (175 aa), Fasta scores: E(): 8.8e-09, 39.6% identity in 96 aa overlap. Also similar to ML1053 a possible orthologue of M. tuberculosis Rv1195. Contains Pfam match to entry PF00934 PE, PE family.
Functional categoryPe/ppe
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS13823291382628-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1183c|PE6
MPLFLNAEPQALTAAANTLEGLSAATVASNAAAAQLTTEIAPPAADDVSILLAHFFSGHGRQYQAHASQGATNHQDLIQSLLTSSSAYAGTETANHDSL
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