Gene ML1195 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameileS
Gene length3180 bp
IdentifierML1195
Location 1410788 bp
Protein summary information
Molecular mass119809.0 Da
Isoelectric point4.77
Protein length1060 amino acids
Structural information
PFAMPF00133, PF08264
Orthologs
M. tuberculosis H37RvRv1536
M. lepromatosis Mx1-22AMLPM_1195
Cross-references
UniProtQ9X7E5
Gene OntologyCytoplasm, Isoleucine-trna ligase activity, Isoleucyl-trna aminoacylation, Zinc ion binding, Atp binding
Enzyme Classification6.1.1.5
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
Productisoleucyl-tRNA synthetase IleS
CommentsML1195, len: 1059 aa. Probable ileS, isoleucyl-tRNA synthase (EC 6.1.1.5). Identical to the previously sequenced Mycobacterium leprae isoleucyl-tRNA synthetase SW:SYI_MYCLE (Q9X7E5) (1059 aa), Fasta scores: E(): 0, 100.0% identity in 1059 aa overlap. Also highly similar to many Prokaryotic and Eukaryotic tRNA synthases e.g. Mycobacterium tuberculosis Rv1536 SW:SYI_MYCTU (Q10765) (1041 aa), Fasta scores: E(): 0, 84.4% identity in 1059 aa overlap and Schizosaccharomyces pombe SW:SYIC_SCHPO (O13651) (1064 aa), Fasta scores: E(): 0, 39.5% identity in 1041 aa overlap. Also similar to ML1472 (valyl-tRNA synthase) from M. leprae. Contains Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V). Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS14107881413967+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1195|ileS
MTNSAYPRTDLGADQRGGSPNFPALEAQVLDYWSNDDTFRASIARCDDAPEYVFYDGPPFANGLPHYGHLLTGYVKDIVPRYRTMCGYKVERRFGWDTHGLPAELEVERQLGITDKSQIDAMGIAAFNEACRKSVLRYTEEWQAYVTRQARWVDFDNDYKTLDLSYMESVIWAFKQLWDKGLAYESYRVLPYCWRDETPLSNHELRMDDDVYQSRQDPAVTLGFKVLGGDDEDLVGAYLLVWTTTPWTLPSNLAVAVHPDVTYVDVRAGDRRFVLAQARLTAYARELGDEPEVLATYRGADLLGRHYLPPFQYFYESARNAFQVLPGDFVTTDDGTGIVHIAPAYGEDDMATADKVGIVPVTPVDSNGCFDATVPDYQGQHVFEANAQIIRDLKNQSGSAAVNGAVLLRHETYEHPYPHCWRCRNPLIYRAVSSWFVAVTEFRDRMVELNQQITWYPEHVKDGQFGKWLQGARDWSISRNRYWGTPIPVWKSDDPDYPRIDVYGSLDELERDFGVRPTNLHRPYIDELTRPNPDDPTGLSTMRRIPDVFDVWFDSGSMPYAQVHYPFENDDWFDGFDSADSDKQVDAHYPGDFIVEYIGQARGWFYTLHVLATALFDRPAFKTCIAHGVVLGSNGQKMSKSLRNYPDVTEIFDRDGSDAMRWFLMASPILRGGNLIITEPGIREGMRQVLLPLWNAYSFLALYAPKIGTWHTDVSHVLDRYILAKLAVLRDDLSQAMEVCDISGACEQLRQFTEPLTNWYLRRSRARFWDEDVDAIDTLHTVLEVTARLAAPLLPLITEIIWRSVTGGRSVHLTDWPQANQLPADPDLVAVMDQVRQVCSAASSLRKAKKLRVRLPLPKLVVAVYNSQRLKPYIDLIGDELNVKQIELTDAIDTYGRFEFTVNARVAGPRLGRDVQAAIKVVKAGEGVANPDGTLTAGPVVLQPDEYSSRLVAANPEFTAELPDGSGLVVLDDTVTPELEAEGWAKDRIRELQELRKLIGLDVSDRIRVLMSVPAERADWARVHRDFIAREILATSFEFGEPADSVAIGDGVRVSLLKV
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