Gene ML1198c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable L-aparaginase AnsA |
| Comments | ML1198c, len: 310 aa. Probable L-asparaginase (EC 3.5.1.1). Identical to the previously sequenced Mycobacterium leprae probable L-asparaginase SW:ASPG_MYCLE (Q9X7E6) (310 aa), Fasta scores: E(): 0, 100.0% identity in 310 aa overlap. Also highly similar to many other L-asparaginases e.g. Mycobacterium tuberculosis Rv1538c SW:ASPG_MYCTU (Q10759) (315 aa), Fasta scores: E(): 0, 72.4% identity in 315 aa overlap and Saccharomyces cerevisiae SW:ASG1_YEAST (P38986) (381 aa), Fasta scores: E(): 6.4e-12, 27.5% identity in 327 aa overlap. Also similar to ML2343 a possible pseudogene similar to M. tuberculosis ansA. Contains Pfam match to entry PF00710 Asparaginase, Asparaginase. Contains PS00917 Asparaginase / glutaminase active site signature 2. Contains PS00144 Asparaginase / glutaminase active site signature 1. Belongs to the asparaginase 1 family. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1416025 | 1416957 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1198c|ansA
MSRLTVIATGGTISTSTDHDGVRRPAYSGTELTAHVAVDVDVVDLMTVDSSQLIPTDWDRIRAAVHTATRNGARGVVVTHGTDTMEETALWLDLTYAGNVPVVLTGAMRSADAPNADGPTNLREALAVAASPAARGVGVLVSFAGRVLQPLGLRKAATQDLSGFAGELLGTSSSGFALTAAKTRPYLGDLCAADAPRVDIVAAYLGSDSVALDAYVSTGARGIVLEALGSGNAGAAVVDGVRRHCHNGIVIAVSTRVPEGHVSAGYGPGHDLVEAGAVLVPWLRPSQVRVLLMAALAANLPIADVIERWG
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