Gene ML1207
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | DNA POLYMERASE III IS A COMPLEX, MULTICHAIN ENZYME RESPONSIBLE FOR MOST OF THE REPLICATIVE SYNTHESIS IN BACTERIA. THIS DNA POLYMERASE ALSO EXHIBITS 3' TO 5' EXONUCLEASE ACTIVITY. THE ALPHA CHAIN IS THE DNA POLYMERASE [CATALYTIC ACTIVITY : N DEOXYNUCLEOSIDE TRIPHOSPHATE = N DIPHOSPHATE + {DNA}(N)]. |
| Product | PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1 (DNA NUCLEOTIDYLTRANSFERASE) |
| Comments | ML1207, len: 1177 aa. Probable dnaE1, DNA polymerase III, alpha chain (EC 2.7.7.7). Identical to the previously sequenced Mycobacterium leprae putative DNA polymerase III alpha chain TR:Q9X7F0 (EMBL:AL049478) (1177 aa), Fasta scores: E(): 0, 100.0% identity in 1177 aa overlap. Also highly similar to DNA polymerases from e.g. Mycobacterium tuberculosis Rv1547 SW:DP3A_MYCTU (Q10779) (1184 aa), Fasta scores: E(): 0, 91.2% identity in 1176 aa overlap and Escherichia coli DnaE or PolC SW:DP3A_ECOLI (P10443) (1160 aa), Fasta scores: E(): 0, 36.1% identity in 1193 aa overlap. Contains Pfam match to entry PF02193 POLIIIAc, DNA polymerase alpha chain like domain. BELONGS TO DNA POLYMERASE TYPE-C FAMILY, DNAE SUBFAMILY |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1423017 | 1426550 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1207|dnaE
MNQSSFVHLHNHTEYSMLDGAAKITPMFAEVERLQMPAVGMTDHGNMFGASEFYNTAIKAGIKPIIGVEAYIAPGSRFDTRRITWGDPSQKADDVSAGGAYTHLTMVAENAAGLRNLFKLSSLASFEGQLSKWSRMDAELIGEYAEGIIVTTGCPSGEVQTRLRLGHDREALESAAKWREIVGPDNYFLELMDHGLSIEQRVREGLLNIGRKLNIPPLATNDCHYVTRDAVHNHEALLCVQTGKTLSDPNRFKFHGDGYYLKSAAEMRQLWDDEVPGACDSTLLIAERVQSYADVWEPRNRMPVFPVPVGHDQASWLRHEVDAGLKRRFPDGPPNGYVERAAYEIDVICDKGFPAYFLIVADLVNHARSVGIRVGPGRGSAAGSLAAYALGITDIDPIPHGLLFERFLNPERTSMPDIDIDFDDRRRGEMVRYAADKWGHDRVAQVITFGTIKTKAALKDSARIHYGQPGFAMADRITKALPPAIMAKDIPLSGITDPAHERFKEAAEVRSLIETDSDVRIIYQTARGLEGLIRNAGVHACAVILSSEPLTEAIPLWKRPQDGAIITGWDYPACEAIGLLKMDFLGLRNLTIIGDAIENIKTNRGIDLDLESVPLDDQATYELLGRGDTLGVFQLDGGPMRDLLRRMQPTGFEDIVAVLALYRPGPMGMNAHNDYADRKNNRQVIKPIHPELEEPLREILAETYGLIVYQEQIMRIAQKVAGYSLARADILRKAMGKKKREVLEKEFEGFSEGMQANGFSVHAIKALWDIILPFADYAFNKSHAAGYGLISYWTAYLKANFAGEYMAGLLTSVGDDKDKAAVYLADCRKFGITVLPPDVNESVLDFASVGADIRYGLGAVRNVGANVVGSLIKTRNAKGKFADFSDYLNKIDITSCNKKVTESLIKAGAFDSLGHSRKGLFLVHADAVDSVLGTKKAEAIGQFDLFGGTDGGTDAVFTIKVPDDEWEDKHKLALEREMLGLYVSGHPLNGVAHLLAAQVDTAIPTILDGGVSNDTQVRVGGILAAVNRRVNKNGIPWASAQLDDLTGGIEVMFFPHTYSSYGADIIDDAVVLVNAKVVVRDDRIALIANQLVVPDFSNVQEDRPLAVSLLTRQCTFDKVNALKQVLARHPGTSQVHLRLISGDRITTLELDQSLRVTSSPALMGDLKALLGPGCLGD
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