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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionDNA POLYMERASE III IS A COMPLEX, MULTICHAIN ENZYME RESPONSIBLE FOR MOST OF THE REPLICATIVE SYNTHESIS IN BACTERIA. THIS DNA POLYMERASE ALSO EXHIBITS 3' TO 5' EXONUCLEASE ACTIVITY. THE ALPHA CHAIN IS THE DNA POLYMERASE [CATALYTIC ACTIVITY : N DEOXYNUCLEOSIDE TRIPHOSPHATE = N DIPHOSPHATE + {DNA}(N)].
ProductPROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1 (DNA NUCLEOTIDYLTRANSFERASE)
CommentsML1207, len: 1177 aa. Probable dnaE1, DNA polymerase III, alpha chain (EC 2.7.7.7). Identical to the previously sequenced Mycobacterium leprae putative DNA polymerase III alpha chain TR:Q9X7F0 (EMBL:AL049478) (1177 aa), Fasta scores: E(): 0, 100.0% identity in 1177 aa overlap. Also highly similar to DNA polymerases from e.g. Mycobacterium tuberculosis Rv1547 SW:DP3A_MYCTU (Q10779) (1184 aa), Fasta scores: E(): 0, 91.2% identity in 1176 aa overlap and Escherichia coli DnaE or PolC SW:DP3A_ECOLI (P10443) (1160 aa), Fasta scores: E(): 0, 36.1% identity in 1193 aa overlap. Contains Pfam match to entry PF02193 POLIIIAc, DNA polymerase alpha chain like domain. BELONGS TO DNA POLYMERASE TYPE-C FAMILY, DNAE SUBFAMILY
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS14230171426550+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium leprae TN|ML1207|dnaE
MNQSSFVHLHNHTEYSMLDGAAKITPMFAEVERLQMPAVGMTDHGNMFGASEFYNTAIKAGIKPIIGVEAYIAPGSRFDTRRITWGDPSQKADDVSAGGAYTHLTMVAENAAGLRNLFKLSSLASFEGQLSKWSRMDAELIGEYAEGIIVTTGCPSGEVQTRLRLGHDREALESAAKWREIVGPDNYFLELMDHGLSIEQRVREGLLNIGRKLNIPPLATNDCHYVTRDAVHNHEALLCVQTGKTLSDPNRFKFHGDGYYLKSAAEMRQLWDDEVPGACDSTLLIAERVQSYADVWEPRNRMPVFPVPVGHDQASWLRHEVDAGLKRRFPDGPPNGYVERAAYEIDVICDKGFPAYFLIVADLVNHARSVGIRVGPGRGSAAGSLAAYALGITDIDPIPHGLLFERFLNPERTSMPDIDIDFDDRRRGEMVRYAADKWGHDRVAQVITFGTIKTKAALKDSARIHYGQPGFAMADRITKALPPAIMAKDIPLSGITDPAHERFKEAAEVRSLIETDSDVRIIYQTARGLEGLIRNAGVHACAVILSSEPLTEAIPLWKRPQDGAIITGWDYPACEAIGLLKMDFLGLRNLTIIGDAIENIKTNRGIDLDLESVPLDDQATYELLGRGDTLGVFQLDGGPMRDLLRRMQPTGFEDIVAVLALYRPGPMGMNAHNDYADRKNNRQVIKPIHPELEEPLREILAETYGLIVYQEQIMRIAQKVAGYSLARADILRKAMGKKKREVLEKEFEGFSEGMQANGFSVHAIKALWDIILPFADYAFNKSHAAGYGLISYWTAYLKANFAGEYMAGLLTSVGDDKDKAAVYLADCRKFGITVLPPDVNESVLDFASVGADIRYGLGAVRNVGANVVGSLIKTRNAKGKFADFSDYLNKIDITSCNKKVTESLIKAGAFDSLGHSRKGLFLVHADAVDSVLGTKKAEAIGQFDLFGGTDGGTDAVFTIKVPDDEWEDKHKLALEREMLGLYVSGHPLNGVAHLLAAQVDTAIPTILDGGVSNDTQVRVGGILAAVNRRVNKNGIPWASAQLDDLTGGIEVMFFPHTYSSYGADIIDDAVVLVNAKVVVRDDRIALIANQLVVPDFSNVQEDRPLAVSLLTRQCTFDKVNALKQVLARHPGTSQVHLRLISGDRITTLELDQSLRVTSSPALMGDLKALLGPGCLGD
      
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