Gene ML1209
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN ISOLEUCINE BIOSYNTHESIS (FIRST STEP). CATALYZES THE FORMATION OF ALPHA-KETOBUTYRATE FROM THREONINE IN A TWO STEP REACTION. THE FIRST STEP IS A DEHYDRATION OF THREONINE, FOLLOWED BY REHYDRATION AND LIBERATION OF AMMONIA [CATALYTIC ACTIVITY : L-THREONINE + H(2)O = 2-OXOBUTANOATE + NH(3) + H(2)O]. |
| Product | Probable threonine dehydratase IlvA |
| Comments | ML1209, len: 427 aa. Probable ilvA, threonine dehydratase (EC 4.2.1.16). Identical to the previously sequenced Mycobacterium leprae probable threonine deaminase TR:Q9X7F1 (EMBL:AL04947) (427 aa), Fasta scores: E(): 0, 100.0% identity in 427 aa overlap. Highly similar to many other threonine dehydratase including: Mycobacterium tuberculosis Rv1559 SW:THD1_MYCT and Corynebacterium glutamicum SW:THD1_CORGL (Q04513) (436 aa), Fasta scores: E(): 0, 60.7% identity in 415 aa overlap. Contains Pfam match to entry PF00585 Thr_dehydrat_C, C-terminal domain of Threonine dehydratase. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme. Contains PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1428254 | 1429537 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1209|ilvA
MSAEPSRNPRTPPVSAVDIDGAAKRIAPVVTPTPLQLSDRLSAITGAAVYLKREDLQTVRSYKLRGAYNLLVQLTDEEIAAGVVCSSAGNHAQGVAYACRSLGVHGRVYVPAKTPKQKWDRIRYHGGAFIELIVGRSTYDLAAAAAVDDIERTGATLVPPYDDVRVIAGQGTIAVELLEQLNTEPDLVVVPVGGGGCIAGMTTYLAERTANTAVLGVEPAGAAAMMAALAAGEPVTLDYVDQFVDGAAVNRVGTLPYAALTAAGDMVSITTVDEGAVCTAMLDLYQNEGIIAEPAGALSVAGLLETDIEPGSTVVCLISGGNNDVLRYGEVLERSLIHLGLKHYFLVDFPQKPGALRRFLDEVLGPNDDITLFEYVKRNNRETGEALVGIQLGSAVDLDVLLARMQGTEMHVETLQPGSPAYRYLLL
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