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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionINVOLVED IN ISOLEUCINE BIOSYNTHESIS (FIRST STEP). CATALYZES THE FORMATION OF ALPHA-KETOBUTYRATE FROM THREONINE IN A TWO STEP REACTION. THE FIRST STEP IS A DEHYDRATION OF THREONINE, FOLLOWED BY REHYDRATION AND LIBERATION OF AMMONIA [CATALYTIC ACTIVITY : L-THREONINE + H(2)O = 2-OXOBUTANOATE + NH(3) + H(2)O].
ProductProbable threonine dehydratase IlvA
CommentsML1209, len: 427 aa. Probable ilvA, threonine dehydratase (EC 4.2.1.16). Identical to the previously sequenced Mycobacterium leprae probable threonine deaminase TR:Q9X7F1 (EMBL:AL04947) (427 aa), Fasta scores: E(): 0, 100.0% identity in 427 aa overlap. Highly similar to many other threonine dehydratase including: Mycobacterium tuberculosis Rv1559 SW:THD1_MYCT and Corynebacterium glutamicum SW:THD1_CORGL (Q04513) (436 aa), Fasta scores: E(): 0, 60.7% identity in 415 aa overlap. Contains Pfam match to entry PF00585 Thr_dehydrat_C, C-terminal domain of Threonine dehydratase. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme. Contains PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS14282541429537+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium leprae TN|ML1209|ilvA
MSAEPSRNPRTPPVSAVDIDGAAKRIAPVVTPTPLQLSDRLSAITGAAVYLKREDLQTVRSYKLRGAYNLLVQLTDEEIAAGVVCSSAGNHAQGVAYACRSLGVHGRVYVPAKTPKQKWDRIRYHGGAFIELIVGRSTYDLAAAAAVDDIERTGATLVPPYDDVRVIAGQGTIAVELLEQLNTEPDLVVVPVGGGGCIAGMTTYLAERTANTAVLGVEPAGAAAMMAALAAGEPVTLDYVDQFVDGAAVNRVGTLPYAALTAAGDMVSITTVDEGAVCTAMLDLYQNEGIIAEPAGALSVAGLLETDIEPGSTVVCLISGGNNDVLRYGEVLERSLIHLGLKHYFLVDFPQKPGALRRFLDEVLGPNDDITLFEYVKRNNRETGEALVGIQLGSAVDLDVLLARMQGTEMHVETLQPGSPAYRYLLL
      
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