Gene ML1216
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA |
| Comments | ML1216, len: 436 aa. Probable bioA, adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62). Identical to the previously sequenced Mycobacterium leprae adenosylmethionine-8-amino-7-oxononanoate SW:BIOA_MYCLE (P45488) (436 aa), Fasta scores: E(): 0, 100.0% identity in 436 aa overlap. Also highly similar to other proteins which have been shown to be involved in the biosynthesis of biotin e.g. Escherichia coli SW:BIOA_ECOLI (P12995) (429 aa), Fasta scores: E(): 0, 50.0% identity in 418 aa overlap BioA and Mycobacterium tuberculosis Rv1568 SW:BIOA_MYCTU (O06622) (437 aa), Fasta scores: E(): 0, 85.1% identity in 436 aa overlap, BioA. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1438600 | 1439910 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1216|bioA
MSGATSGLTPEQIGAIDAAHLWHPYSTIGAATGVIPPVVAVAAHGAWLTLIRDGKPIEALDAMSSWWTAIHGHGHSVLDAALTTQLGAMNHVMFGGLTHEPAARLAQLLVDITPAGLETVFFSDSGSVSVQVAVKMALQYWRSRGQPAKRRLMTWRGGYHGDTLTPMSICDPDGGMHSLWTDILARQVFAPQVPRDYDPAYSKAFETQLAQHTPELAAVVVEPVVQGAGGMRFHDPRYLCDVRDICRRHDVLLIFDEIATGFGRTGELFAADHCGVSPDIMCVGKALTGGYLSLAATLCTTDIAHAISVGAAGALMHGPTFMANPLACAVSVASVEVLLGQDWRSRVAEISAGLTAGLEAAQGLPGVIDVRVCGAIGVIECDRSVDLAVATPAALDRRVWLRPFRNLVYAMPPYICPPAEIAQITSAMVEVAGLVG
Bibliography
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