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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA
CommentsML1216, len: 436 aa. Probable bioA, adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62). Identical to the previously sequenced Mycobacterium leprae adenosylmethionine-8-amino-7-oxononanoate SW:BIOA_MYCLE (P45488) (436 aa), Fasta scores: E(): 0, 100.0% identity in 436 aa overlap. Also highly similar to other proteins which have been shown to be involved in the biosynthesis of biotin e.g. Escherichia coli SW:BIOA_ECOLI (P12995) (429 aa), Fasta scores: E(): 0, 50.0% identity in 418 aa overlap BioA and Mycobacterium tuberculosis Rv1568 SW:BIOA_MYCTU (O06622) (437 aa), Fasta scores: E(): 0, 85.1% identity in 436 aa overlap, BioA. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS14386001439910+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium leprae TN|ML1216|bioA
MSGATSGLTPEQIGAIDAAHLWHPYSTIGAATGVIPPVVAVAAHGAWLTLIRDGKPIEALDAMSSWWTAIHGHGHSVLDAALTTQLGAMNHVMFGGLTHEPAARLAQLLVDITPAGLETVFFSDSGSVSVQVAVKMALQYWRSRGQPAKRRLMTWRGGYHGDTLTPMSICDPDGGMHSLWTDILARQVFAPQVPRDYDPAYSKAFETQLAQHTPELAAVVVEPVVQGAGGMRFHDPRYLCDVRDICRRHDVLLIFDEIATGFGRTGELFAADHCGVSPDIMCVGKALTGGYLSLAATLCTTDIAHAISVGAAGALMHGPTFMANPLACAVSVASVEVLLGQDWRSRVAEISAGLTAGLEAAQGLPGVIDVRVCGAIGVIECDRSVDLAVATPAALDRRVWLRPFRNLVYAMPPYICPPAEIAQITSAMVEVAGLVG
      
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