Gene ML1218 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namebioD
Gene length681 bp
IdentifierML1218
Location 1441071 bp
Protein summary information
Molecular mass22905.3 Da
Isoelectric point4.81
Protein length227 amino acids
Orthologs
M. tuberculosis H37RvRv1570
M. lepromatosis Mx1-22AMLPM_1218
Cross-references
UniProtP45486
Gene OntologyBiotin biosynthetic process, Dethiobiotin synthase activity, Magnesium ion binding, Atp binding
Enzyme Classification6.3.3.3
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable dethiobiotin synthetase BioD
CommentsML1218, len: 226 aa. Probable bioD, dethiobiotin synthetase (EC 6.3.3.3). Identical to the previously sequenced Mycobacterium leprae dethiobiotin synthetase (EC 6.3.3.3) SW:BIOD_MYCLE (P45486) (223 aa), Fasta scores: E(): 0, 99.6% identity in 223 aa overlap. Also highly similar to several others involved in biotin biosynthesis e.g. Mycobacterium bovis SW:BIOD_MYCBO (O52587) (226 aa), Fasta scores: E(): 0, 74.2% identity in 225 aa overlap and Mycobacterium tuberculosis Rv1570 SW:BIOD_MYCTU (O06620) (226 aa), Fasta scores: E(): 0, 74.2% identity in 225 aa overlap.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS14410711441751+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1218|bioD
LTVVVVTGTDTGVGKTVACAALACHARQAGIEVAVCKPVQTGTQIGDDDLAEVARLSGVTELTGLVRYPQPLAPAAAAEHAGMALPTREQLLELIAGLDRPGRLILVEGAGGLLVELADASATLRDLAVELGALALVTVSVELGTLNHTALTLEALTTRGVACAGLVIGSWTGRPGAVQISNRSALARLAPMRATLPAGAGSMDATDFAAMSAAAFDRDWVTTLVH
Bibliography
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