Gene ML1225 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namenadA
Gene length1059 bp
IdentifierML1225
Location 1446716 bp
Protein summary information
Molecular mass37886.1 Da
Isoelectric point4.69
Protein length353 amino acids
Structural information
PFAMPF02445
Orthologs
M. tuberculosis H37RvRv1594
M. lepromatosis Mx1-22AMLPM_1225
Cross-references
UniProtQ49622
Gene OntologyNad biosynthetic process, Cytoplasm, Iron ion binding, Quinolinate synthetase a activity, Transferase activity, 4 iron, 4 sulfur cluster binding
Enzyme Classification2.5.1.72
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable quinolinate synthetase A NadA
CommentsML1225, len: 352 aa. Probable nadA, quinolinate synthetase. Identical to the previously sequenced Mycobacterium leprae probable quinolinate synthetase A TR:Q49622 (EMBL:U00010) (368 aa), Fasta scores: E(): 0, 100.0% identity in 352 aa overlap. Also similar to quinolinate synthetases from Escherichia coli SW:NADA_ECOLI (P11458) (347 aa), Fasta scores: E(): 2.6e-27, 33.3% identity in 330 aa overlap and Mycobacterium tuberculosis Rv1594 TR:O06596 (EMBL:Z95586) (349 aa), Fasta scores: E(): 0, 84.4% identity in 352 aa overlap. Belongs to the quinolinate synthetase A family. Subfamily 2.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS14467161447774+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1225|nadA
VTVLNGMEPLAGDMTVVIAGITDSPVGYAGVDGDEQWATEIRRLTRLRGATVLAHNYQLPAIQDIADYVGDSLALSRIAAEVPEETIVFCGVHFMAETAKILSPNKTVLIPDQRAGCSLADSITPDELCAWKDEHPGAAVVSYVNTTAEVKALTDICCTSSNAVDVVESIDPSREVLFCPDQFLGAHVRRVTGRKNVYVWMGECHVHAGINGDELVDQARANPDAELFVHPECGCSTSALYLAGEGAFPPDRVKILSTGGMLTAARQTQYRKILVATEVGMLYQLRRAAPEIDFRAVNDRASCKYMKMITPGALLRCLVEGTDEVHVDSEIAAAGRRSVQRMIEIGLPGGGE
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