Gene ML1227 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namenadC
Gene length861 bp
IdentifierML1227
Location 1449351 bp
Protein summary information
Molecular mass30534.1 Da
Isoelectric point4.89
Protein length287 amino acids
Structural information
PFAMPF01729, PF02749
Orthologs
M. tuberculosis H37RvRv1596
M. lepromatosis Mx1-22AMLPM_1227
Cross-references
UniProtP46714
Gene OntologyNicotinate-nucleotide diphosphorylase (carboxylating) activity, Nad biosynthetic process
Enzyme Classification2.4.2.19
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable nicotinate-nucleotide pyrophosphatase NadC
CommentsML1227, len: 286 aa. Probable nadC, nicotinate-nucleotide pyrophosphatas (EC 2.4.2.19). Identical to the previously sequenced Mycobacterium leprae nicotinate-nucleotide pyrophosphorylase [carboxylating] (quinolinate phosphoribosyltransferase [decarboxylating]) SW:NADC_MYCLE (P46714) (284 aa), Fasta scores: E(): 0, 100.0% identity in 284 aa overlap. Also highly similar several others from to Mycobacterium tuberculosis Rv1596 SW:NADC_MYCTU (O06594) (285 aa), Fasta scores: E(): 0, 79.2% identity in 283 aa overlap and Escherichia coli SW:NADC_ECOLI (P30011) (296 aa), Fasta scores: E(): 2.6e-32, 40.4% identity in 272 aa overlap. Contains Pfam match to entry PF01729 QRPTase, Quinolinate phosphoribosyl transferase.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS14493511450211+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1227|nadC
LIMLSDCEFDAARDTIRRALHEDLRYGLDITTQATVPAGTVVTGSMVPREPGVIAGVDVALLVLDEVFGVDGYRVLYRVEDGARLQSGQPLLTVQAAARGLLTAERTMLNLVCHMSGIATVTVAWVDAVRGTKAKIRDTRKTLPGLRALQKYAVRVGGGVNHRLGLGDTALIKDNHVAAVGSVVDALRAVRAAAPELPCEVEVDSLEQLDAMLAEEPELILLDNFPVWQTQVAVQRRDIRAPTVLLESSGGLSLENAAIYAGTGVDYLAVGALTHSVRILDIGLDL
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