Gene ML1229
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 |
| Comments | ML1229, len: 2118 aa. Probable pks4, polyketide beta-ketoacyl synthase. Highly similar at the N-terminus to O50436|Rv1180 pks3 Beta-ketoacyl synthase from M. tuberculosis (488 aa), fasta scores: E(): 5.7e-150, (81.352% identity in 488 aa overlap) and in the C-terminus to O50437|Rv1181 pks4, Polyketide synthase from M. tuberculosis (1582 aa), fasta scores: E(): 0, (75.326% identity in 1609 aa overlap). In M. tuberculosis pks3 and pks4 may represent separate modules of the polyketide synthase. Highly similar to many polyketide synthases involved in the biosynthesis of mycocerosyl lipids e.g. Mycobacterium tuberculosis probable mycocerosic acid synthase Rv2940c TR:P96291 (EMBL:Z83858) (2111 aa), Fasta scores: E(): 0, 60.8% identity in 2127 aa overlap and Mycobacterium bovis mycocerosic acid synthase SW:MCAS_MYCBO (Q02251) (2110 aa), Fasta scores: E(): 0, 58.8% identity in 2127 aa overlap. Highly similar to many other M. leprae polyketide synthases ML0101, ML0135, ML0139, ML2353, ML2354, ML2355, ML2356 and ML2357. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00606 Beta-ketoacyl synthases active site. |
| Functional category | Lipid metabolism |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1454302 | 1460658 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1229|pks4
LRAANVTPVAVIGMACRLPGGIDSPQRLWEALLRGDDLVTEIPKERWDADLYYDPEPGVPGRSVSRWGAFLDDVGGFDCDFFGMTEREAIAIDPQHRLLLETSWDAIEHAGLDPATLAGSATGVFVGLTHGDYELLSADCGATEGPYGFTGTSNSFASGRVAYTLGLHGPAVTVDTACSSGLMAVHQARGSLDCGESDLALAGGVVVTLEPRKSVSGSLQGMLSPTGRCHAFDVAADGFVSGEGCVVLLLKRMPDAERDGDRILAVLRGTAANQDGHTVHIAAPSEQAQIAVYHKALAVGGVDPTTVGLIEAHGTGTPVGDPIEYASLAAVYGTAGRCALASTKTNFGHMQSTSGPLGMMKAILALQHGVVPKNLHFTRLPDQLAEITTELFVPQVNTPWPVDVQQPRRAAVSSYGMSGTNVHAILEQAPENSGKDSPAVSKVNGPLLFPLSATSVEQLRATAARMADWVDEHGSGTKHTGLWDLGYTLSRRRGYRPVRTMVLASSFAELSRGLREIAGSEIPYQSAVGQDDRGPVWVFSGQGSQWAGMGAELFAKEPVFAAAIAAMEPVIVEESGFSVTEALTVAEKVTGIDRVQPTIFAIQVALAATMKSYGVYPGAVIGHSLGEAAAAVAAGALSCEDGLRVICRRSQLMSRVAGSGAMASVELPGQQVLSELSIRGLSDVVLAVVASPTSTVVGGDTQAIRHLLAAWQAQDVMVREVAVDVASHTPQVEPILDDLVETLADLKPTEPKVPYYSATLWDPRERPSFTGEYWAENLRYTVRFAAAVQAALKDGFRVFGELAPHPLLTYAIEQNAASLDMPVSALAAMRREQELPFGLRGFIADVHSAGALVDFSVQYPNGCLVDAPLPTWTRRELMLSRESVDHPAHGAAVQAVHPLLGAHVHLFEEPERHVWQGRVGTEAHPWLGDHQIHDVAAFPGAAYCEMALTAARVTLGEASEVRDIKFEQTLLLDRETMASSAATVSAPGVLEFAVETYEEGERVRRASAVLRALEDRVNQQPASHSIDALIASHPLRTEGADLRATFDAIGIQYGLAFSGLTAVYTAAGTNEDVSTVLAEVALPGAIRSQQASYTSHPALLDACFQSVIVAPEVQKAGAGGLLLPVYVRRLLNYHSMRNAQYCLTRVKTSRAGECEVDLEVLDQSGAVLLLVEGLRLAGGASEHECANRVLDERLFTVEWEPRELPEVTQRERGSWLVLGASAEDPLVQQLGDALNADGGHCTAVSLPLGQIDTAQLCSLLSRDGVSSSIGHGALKGLTGVVVVTAPPATVAESPALRRGRDYVSHLITIVREISELPGERPRLFVVTRNAASIKTGDLANLEQVGLRGLIRVIDSEHPYLSVTQIDVEETNQATIATQVARQLRSGSDEDETGWRDGEWYTARLRPGPLRQAERRTVVVQNEHDGMRLEIRTPGDLDSLEFVAFDRVPPGPGEIEVAVTASTVNFADVLVAFGRYPTFEGYCQLLGIDFAGVVSAVGLNVTDHKVGDRVGGVSRNGCWTTFVICDARHAVTLSPEVPLEEAAAVPTVAATAWYGLHDLARISQTDKVLIHSGTGGVGQAAIAIARAAGCEIFATAGSPQRRQLLRDKGIEHVYDSRSLEFAEQIHRDTKGYGVDVVLNSLPGAAQRAGIELLAFGGRFVEIGKRDIYGDTRLGLFPFRRNLSLYAVDLALLTYTHPDTVRRLLTTVYQRTAEGVLPVPQTTHYPIHNTANAVRLVAGAGHTGKVLLDVPHTGSSVAVVPPEQVRTFRADGAYIVTGGLTGLGLFLGTEMAAAGCGRIVLNSRSAPNPQAQETIERLRAGGADIQVECGDIAEPRVADRLVVAATQSGLPVRGVLHAAGVVEDATLTNVTDDLIDRCWAPKVYGAWNLHQALQEGKTAQLLDWFCSFSTAAALVGSPGQGAYAAANSWLDGFSYWRRAQGLASTTIAWGAWGELGLATALAEMAGVAIAPTEGARVFQTLLRYNRPYSCYAPIMETPWLKSFAQHSRFAEAFRSISQGQKDKSKFLAELKVLPRDEWPSMIRRLVSEQISLLLRRTIDPDRLLSDYGLDSLGNLELRTRIETETGIRISPTKITTIRSLAEHLCEELAATEAESAVTAT
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