Gene ML1231 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namemmpL10
Gene length2952 bp
IdentifierML1231
Location 1462236 bp
Protein summary information
Molecular mass104088.0 Da
Isoelectric point8.33
Protein length984 amino acids
Structural information
PFAMPF03176
Orthologs
M. tuberculosis H37RvRv1183
M. lepromatosis Mx1-22AMLPM_1231
Cross-references
UniProtQ49619
Gene OntologyPlasma membrane, Integral to membrane
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL10
CommentsML1231, len: 983 aa. Probable mmpL10, conserved transmembrane transport protein. Previously sequenced Mycobacterium leprae membrane protein MMPL10 SW:MMLA_MYCLE (Q49619) (1008 aa), Fasta scores: E(): 0, 100.0% identity in 983 aa overlap. Also highly similar to many MMPL-family Mycobacterium tuberculosis proteins e.g. Rv1183 SW:MMLA_MYCTU (O50439) (1002 aa), Fasta scores: E(): 0, 70.4% identity in 978 aa overlap. Also similar to ML2378 and ML0137 from M. leprae. Contains possible membrane spanning hydrophobic domains.
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS14622361465187+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1231|mmpL10
VVIGCWTLLALMLPMTVPSLTELTQRHPVVILPVDAPSSVAAKKISQAFHEVDSENVLIVLLTDDKGLGPADETVYRTLVDRLRNDTKDVVVLQDFLSTPPLHELLVSKDGKAWILPIVLAGELGTSASYQAYAGVAGIVKQTLESTAGSSLKANLTGPASTVADLTDAGARDRTSIELVIAVLLLTILMIIYRNPITMLLPLITIGASLMTAQAVVSGVSVLAGLAVSNQMIVLLSAMIAGAGTDYAVFLISRYHDYIRMGSGSAQDAGCAVRQALISLGKVIAASAATVGITFLGMSFTKIRVFSTVGPALAIGIAVAFLAAVTLMPALLVLAGTRGWVAPRRDRAGAFWRRTGVRIVRRPVAYLSASMVILIVLALCASLVRFNYDDRKQIPASDESSVGYAALESHFPVGQAIPEYLLIQSPHDLRTPRALADMAELAQRVSQIPGIALVRGVTRPTGKPLEETSATYQAGMVGKQLGSASHLIGESTGDLNRLASGAGLLADKLGDVRIQVGQAVAGISGLLDNLAFAQKMFGDSKTLGEIDTAGKLVSSMRALGNMFGINFSTTMNDINWVGAVVIALDSSVLCDTNPICADARAQFHKLLTASEDGTLDNIAHLWKQLGSTQSSQTIGATVSGLEKTLTAVNTSLRSLGLDNPNVMRSKMIGLQNGVNDLASAGRRIADGVAVLVDQTRTMGTSLARASAFLMEMGQDASQPSMAGFNVPPQLLNTEDFKKLVQAFISPDGHSVRYFIQTDLNPFSSAAMDQVNTILNVATGAQPNTTLSDASIYLSGYTVTLRDTRDYYDRDLQLIVIVTMIVVLLILMALLRSIVAPIYLVGSVIVSYLSALGLCVLVFQVLLRQQLHWSVPGLAFVVLVAVGADYNMLLASRLRDESSHGLRASVIRTVRSTGGVITAAGLIFAASMFGLLLSSIATVVQAGFVLGSGILLDTFIVRTITVPAVAALLRRASWWPARPWGNNA
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