Gene ML1234c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namefadD21
Gene length1740 bp
IdentifierML1234c
Location 1467578 bp
Protein summary information
Molecular mass63102.3 Da
Isoelectric point5.65
Protein length580 amino acids
Structural information
PFAMPF00501
Orthologs
M. tuberculosis H37RvRv1185c
M. lepromatosis Mx1-22AMLPM_1234
Cross-references
UniProtP54200
Gene OntologyLigase activity, Fatty acid metabolic process
Enzyme Classification6.2.1.-
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)
CommentsML1234c, len: 579 aa. Probable fadD21, fatty-acid-CoA synthetase (EC 6.2.1.-). Highly similar to acyl-CoA synthases from Mycobacterium tuberculosis Rv1185c TR:O50441 (EMBL:AL010186) (578 aa), Fasta scores: E(): 0, 72.4% identity in 579 aa overlap and Mycobacterium bovis TR:P71495 (EMBL:U7568) (582 aa), Fasta scores: E(): 0, 63.4% identity in 579 aa overlap. Also similar to ML0100, ML0132, ML0138, ML0243 and ML2358 from M. leprae. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme.
Functional categoryLipid metabolism
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS14675781469317-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1234c|fadD21
MQNSSVLSFLRERAGLQPDDEAFSFTDYEQDWAGVRKTLTWAQLYQRTLNVAHELRRHGSIRDRAVILAPQGLDYIIAFLGAMQAGFIAVPLSVPQAGSHDERVGAVLADTSPSVVLTTSAVADAIAKYVDHSDTDTVPAILEVDSPNLDVENKSNIRLTDAPSTAYLQYTSGSTRLPAGVMVTHRNLMVNFQQLMADYFAPTNGVAPLDLTIVSWLPFYHDMGLVLGVVAPILGGWRSELTSPISFLQRPARWIQAMATSSHPFSAGPNFAFELAARRTSDADIAGLDLGACQGIISGSERIHPATLNRFSDRFARINFRDDMMLPSYGLAEGTVYAASRPKGSSPEVVYFEPAKLSEGTVKRCEARTGAPLLSYGTPKSPIVRIVDSDTCIECPTGRVGEIWLHGDNVAEGYWHKPEETQRTFGGKLANPSPGTPEGPWLRTGDLGFISEDELFIVGRMKDLLIVYGRNHYPEDIESTVQEITGGRVAAISVPVDETEKLVTIIEVKKRGDSDAEAMQKLVAVKNNITAAISKSHGLNVADLVLVPPGSIPTTTSGKVRRTACVEQYRRQQFSRLDG
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