Gene ML1246 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameplsB
Gene length2328 bp
IdentifierML1246
Location 1486028 bp
Protein summary information
Molecular mass87331.7 Da
Isoelectric point7.27
Protein length776 amino acids
Structural information
PFAMPF01553
Orthologs
M. tuberculosis H37RvRv2482c
M. lepromatosis Mx1-22AMLPM_1246
Cross-references
UniProtQ9X7B0
Gene OntologyPhospholipid biosynthetic process, Plasma membrane, Glycerol-3-phosphate o-acyltransferase activity
Enzyme Classification2.3.1.15
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE PLSB2 (GPAT)
CommentsML1246, len: 775 aa. Probable plsB2, glycerol-3-phosphate acyltransferase (EC 2.3.1.15). Highly similar to many acyltransferases including: Escherichia coli glycerol-3-phosphate acyltransferase (EC 2.3.1.15) SW:PLSB_ECOLI (P00482) (806 aa), Fasta scores: E(): 1.5e-27, 24.4% identity in 693 aa overlap and Mycobacterium tuberculosis putative acyltransferase PlsB2 Rv2482c SW:PLS2_MYCTU (O53207) (789 aa), Fasta scores: E(): 0, 80.7% identity in 783 aa overlap. Contains Pfam match to entry PF01553 Acyltransferase, Acyltransferase.
Functional categoryLipid metabolism
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS14860281488355+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1246|plsB
VTEPDVEISSVLTGEDTLVLASMDTPAEIELVMDWLCQQRNRNPDIKFDVLKLPSRNLAPAALTALVEQLESDEDRSVVPVRVFWMPPAERSKLAKLAGLLPGRDPYHPNRRQQRHILKTDARRALVIAGDSAKVSELRQYWRDTTVGENECDFAQFVTRRAILAMERAESRILGPQYKSPRLVKPEILASTRFRAGLEKISGATVEEAGKMLDELATGWSRASVDLVSVLGRMLSRGFEPEIDYDEYQVAAMRAALEAHPAVLLFSHRSYIDGAVVPVAMQENRLPPVHVFAGINLSFGLMGPLLRRSGVIFIRRNIGDNPLYKYVLREYVGYIVEKRFNLSWSIEGTRSRTGKMLPPKLGLLTYVADAYLDGRSEDILLQPVSISFDQLHETAEYAAYARGGEKTPEGVAWLYSFIKAQGERNYGKIYVRFPEAVSMRQYLGAPHGALVQDQDAKRLALQKMSFEVAWRILCATPVTATALVSALLLTTRGVALTLDQLHHTLQESLDYLERKQTPVSKSALRLRSREGVRAAVDALSSGHPITRVDSGREPVWYITPGNEHAAAFYRNSVIHAFLETSIVELALAHARHVEGDRMKVFWAQAMRLRDLLKFDFYFADSAAFRANIAEEIAWHQNWEDRVSGDGDDIDAMLLTKRPLISDAMLRVFFEAYDIVADVLRDAPADVGQKELTELALGVGRQYVAQGRVRSGESVSTLLFATAYQVVVDQNLIAPAPDLAERRMVFRRELRDIRRDFDYVEQIARSRFIVREFKSR
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