Gene ML1249 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namegdh
Gene length4869 bp
IdentifierML1249
Location 1490902 bp
Protein summary information
Molecular mass177876.0 Da
Isoelectric point5.48
Protein length1623 amino acids
Structural information
PFAMPF05088
Orthologs
M. tuberculosis H37RvRv2476c
M. lepromatosis Mx1-22AMLPM_1249
Cross-references
UniProtQ7AQ79
Gene OntologyCatalytic activity, Metabolic process, Binding
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE NAD-DEPENDENT GLUTAMATE DEHYDROGENASE GDH (NAD-GDH) (NAD-DEPENDENT GLUTAMIC DEHYDROGENASE)
CommentsML1249, len: 1622 aa. Probable gdh, NAD-dependent glutamate dehydrogenase (EC 1.4.1.2). Similar to several NAD-dependent glutamate dehydrogenase including: Mycobacterium tuberculosis Rv2476c TR:O53203 (EMBL:AL021246) (1624 aa), Fasta scores: E(): 0, 81.5% identity in 1634 aa overlap and Rickettsia prowazekii TR:Q9ZCI2 (EMBL:AJ235273) (1581 aa), Fasta scores: E(): 0, 32.9% identity in 1494 aa overlap.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS14909021495770+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1249|gdh
MTIDPGATHVAELCTTFTQGADVPDWISKAYIDSYRGSHGDVREAPETSRVNPNALVTPAMLSAHYRLGQCRPNGRNCVRVYPADDPAGFGPALQIVTDHGGMVMDSITVLLHRLGVTYTAMMTPVFMVLRSPTGELLGVEPRASSTSHSIEGTWVGEVWIYIQLLPAVDSKSLAEVEQLLPRTLVDVQRVAADAAALNATLSGLAADVKTNKEGHFSASDRDDVAALLHWLGNGNFLLLGYQRCRVHYGLVSCDRSTGLGVLRARTGSRPRLTDDNELLVLAQAAVGNYLRYGAYPYAIAVREYDDGGDGGIIEHRFVGLFTVAAMNADVLEIPSISHRVRAALAMANSDPIYPGQLLLDVIQTVPRSELFTLSAERLFTMAKEVVDLGSGRRALLFLRADRLQYFVSCLVYVPRDRYTTGVRLQIEDILVREFGGTQVEFTARVSESPWALMHFMVRLSEGAATGSVDVSEGNRIRIQAMLSEAARTWSDRLIAAAASFSEGSVSYAEAEHYAATFSETYKQAVTPADAIDHIAIIKELADDSVKLVFFERKADGFAQLTWFLGGRSASLSQLLPMLQSMGVVVLEERPFTVARTDGLPVWIYQFKISPHPTIPLASTANERELTAKRFSDAVTAIWQGRVEIDRFNELVMRARLTWQQVVLLRAYAKYLRQAGFNYSQSYIESVLNEHPSTARSLVALFEALFDPSPLSSSTNCDAQAAAAAVAADIDALVSLDTDRILRAFASLVQATLRTNYFVTQKFSARSKGVLVLKLDAQLINELPLPRPKFEIFVYSPRVEGVHLRFGAVARGGLRWSDRLDDFRTEILGLVKAQAVKNAVIVPVGAKGGFVLKRPPLPTGDAAADRDAMRAEGIACYQLFISGLLDITDNVDHATGKVNAPPQVVRRDSDDAYLVVAADKGTATFSDIANDVAKSYGFWLGDAFASGGSVGYDHKAMGITAKGAWEAVKRHFREMGVDTQNEDFTVVGIGDMSGDVFGNGMLLSKHIRLIAAFDHRHVFLDPDPDAAVSWAERQRMFDLPRSSWDDYNKSLISEGGGVYSREQKAIPTSPQVRTALGIDGEVTEMAPPNLIRAILQAPVDLLFNGGIGTYIKAETESVADVGDRANDPVRVNANQVRAKVIGEGGNLGVTALGRVEFDLSGGRINTDAMDNSAGVDCSDHEVNIKILIDSLVTAGKVKVEERKHLLESMTDEVARLVLTDNEDQNDLIGTSRANAANMLSVHAMQIKYLVDERGVNRELEALPSEKEIQRRSEAGIGLTSPELSTLMAHVKLALKEQMLATELPDQDVFVSRLPRYFPKPLRERFTPEIRSHQLRREIVTTMLINDLVDTAGISYAFRIAEDIGVGPIDAIRTYVATDAIFGVGDVLRRIRAANLSVVLSDRMTLDTRRLIDRAGRWLLNYRPQPLAVGAEINRFAAKVKALTPRMSEWLRGDDQAIVEQQATEFVSQGAPEDLAYRVAVGLYRYSLLDIIDIADITELDPAEVADTYFSLMDRLGTDGLLTAVSKLPQNDRWHSLARLAIRDDIYASLRSLCFDVLAVGEPDESGEEKIAEWEHISASRVERARLMLAEIHASGEKDLATLSVAARQIRRMTRTSGRGSSG
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