Gene ML1257
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Involved in histidine biosynthesis pathway (last step). THIS PROTEIN IS CONSIDERED AS A BIFUNCTIONAL ENZYME, POSSESSING TWO ACTIVE SITES, ONE AN ALCOHOL DEHYDROGENASE AND THE OTHER AN ALDEHYDE DEHYDROGENASE [CATALYTIC ACTIVITY : L-HISTIDINOL + 2 NAD(+) + H(2)O = L-HISTIDINE + 2 NADH]. |
| Product | Probable histidinol dehydrogenase HisD (HDH) |
| Comments | ML1257, len: 449 aa. Probable hisD, histidinol dehydrogenase (EC 1.1.1.23). Highly similar to many histidinol dehydrogenases constituting the first stage in the histidine biosynthetic pathway e.g. Mycobacterium tuberculosis Rv1599 SW:HISX_MYCTU (Z95586) (438 aa), Fasta scores: E(): 0, 84.8% identity in 442 aa overlap and Mycobacterium smegmatis SW:HISX_MYCSM (P28736) (445 aa), Fasta scores: E(): 0, 77.5% identity in 449 aa overlap. Contains Pfam match to entry PF00815 Histidinol_dh, Histidinol dehydrogenase. Contains PS00611 Histidinol dehydrogenase signature. Belongs to the histidinol dehydrogenase family. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1502300 | 1503649 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1257|hisD
VSITPPFLLACIDLRGAELTATQLRATLPRGGADVEAVLPTVWPIVQAVAECGADAALEFGALFDGVRPPTVRVPDAALDAALAGLDPDVRDALQVMIERTRVVHADQRRTDVTTALGPGATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQTAGVDSLVVASPPQFTSGGRFHGLPHPTILAAARLLGVDEVWAVGGAQAVALLAYGGTDSDDCELAPVDMITGPGNIYVTAAKRLCRSRVGIDGEAGPTEIAILADHTADPAHVAADMISQAEHDEMAASVLVTPSTDLADATDAELAAQLRTTVHRKRVVAALGGRQSAIILVDDLEAGVKVVNLYAAEHLEIQTAEASRVASRIRCAGAIFVGPWAPVSLGDYCAGSNHVLPTAGFARHSGGLSVQTFLRGIHVVNYTKTALKDISGHVITLAKAEDLPAHGEAVRRRFAR
Bibliography
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