Gene ML1258 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namehisC
Gene length1134 bp
IdentifierML1258
Location 1503646 bp
Protein summary information
Molecular mass40350.8 Da
Isoelectric point5.21
Protein length378 amino acids
Structural information
PFAMPF00155
Orthologues
M. tuberculosisRv1600
Cross-references
UniProtQ9X7B8
Gene OntologyHistidinol-phosphate transaminase activity, Pyridoxal phosphate binding, Histidine biosynthetic process
Enzyme Classification2.6.1.9
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable histidinol-phosphate aminotransferase 1 HisC (Imidazole acetol-phosphate transaminase 1)
CommentsML1258, len: 377 aa. Probable hisC, histidinol-phosphate aminotransferase 1 (EC 2.6.1.9). Highly similar to many histidinol-phosphate aminotransferases involved in histidine biosynthesis e.g. Mycobacterium tuberculosis Rv1600 TR:SW:HIS8_MYCTU (O06591) (380 aa), Fasta scores: E(): 0, 83.6% identity in 366 aa overlap and Mycobacterium smegmatis SW:HIS8_MYCSM (P28735) (219 aa), Fasta scores: E(): 0, 77.2% identity in 219 aa overlap. Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II. BELONGS TO CLASS-II OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. HISTIDINOL-PHOSPHATE AMINOTRANSFERASES SUBFAMILY
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS15036461504779+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1258|hisC
MNVPEPTLDDLPLRDNLRGKSPYGAMQLLVPVLLNTNENPHPPTKALVDDVVRSVQKVAVDLHRYPDRDAVALRQDLASYLTAQTGIRLGVENIWAANGSNEILQQLLQAFGGPGRSAIGFVPSYSMHPIIADGTHTEWLETVRADDFSLDVEAAVTAVADRKPDVVFIASPNNPSGQSISLADLRRLLDVVPGILIVDEAYGEFSSRPSAVALVGEYPTKIVVTRTTSKAFAFAGGRLGYLIATPALVEAMLLVRLPYHLSSVTQAAARAALRHADDTLGSVAALIAERERVTKSLVHMGFRVIPSDANFVLFGHFSDAAGAWQHYLDTGVLIRDVGIPGYLRATTGLAEENDAFLKASSEIAATELAPATTLGAS
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