Gene ML1261 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namehisA
Gene length738 bp
IdentifierML1261
Location 1506035 bp
Protein summary information
Molecular mass26116.4 Da
Isoelectric point4.41
Protein length246 amino acids
Structural information
PFAMPF00977
Orthologs
M. tuberculosis H37RvRv1603
M. lepromatosis Mx1-22AMLPM_1261
Cross-references
UniProtQ9CC56
Gene OntologyCytoplasm, Histidine biosynthetic process, Phosphoribosylanthranilate isomerase activity, Tryptophan biosynthetic process, 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity
Enzyme Classification 5.3.1.24, 5.3.1.16
Precomputed results
BLASTReport
General annotation
TypeCDS
Functionhistidine biosynthesis pathway (fourth step) [CATALYTIC ACTIVITY : 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide = 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide..]
ProductPROBABLE PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDE ISOMERASE HISA (1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase)
CommentsML1261, len: 245 aa. Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16). Highly similar to many phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerases involved in histidine biosynthesis including: Mycobacterium tuberculosis Rv1603 SW:HIS4_MYCT (O0658) (245 aa), Fasta scores: E(): 0, 84.4% identity in 244 aa overlap and Streptomyces coelicolor SW:HIS4_STRCO (P16250) (240 aa), Fasta scores: E(): 0, 66.3% identity in 240 aa overlap. Contains Pfam match to entry PF00977 His_biosynth, Histidine biosynthesis protein. Belongs to the hisA / hisF family.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS15060351506772+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1261|hisA
LMSLILLPAVDVVEGRAVRLVQGKAGSENDYGSALDAALCWQRDGADWIHLVDLDAAFGRGSNRELLSEMVGKLDVQVELSGGIRDDDSLNAALATGCARVNLGTAACENPHWCAQVIAEHGDKIAVGLDVQIVDGQHRLRGRGWETDGGDLWDVLENLDRQGCSRFIVTDVTKDGTLDGPNLDLLASVSDRTNVPVIASGGVSSLDDLRAIAKFTERGIEGAIVGKALYAERFTLPQALAVVRM
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