Gene ML1263
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | histidine biosynthesis pathway (fifth step). IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The hisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the hisH subunit [CATALYTIC ACTIVITY: 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H2O]. |
| Product | Imidazole glycerol phosphate synthase subunit HisF (IGP synthase cyclase subunit) (IGP synthase subunit hisF) (ImGP synthase subunit hisF) |
| Comments | ML1263, len: 261 aa. Probable hisF, Imidazole glycerol phosphate synthase subunity. Highly similar to many cyclases involved in histidine biosynthesis including: Mycobacterium tuberculosis Rv1605 SW:HIS6_MYCTU (O53908) (267 aa), Fasta scores: E(): 0, 89.8% identity in 256 aa overlap and Bacillus subtilis SW:HIS6_BACSU (O34727) (252 aa), Fasta scores: E(): 0, 53.0% identity in 253 aa overlap. Contains Pfam match to entry PF00977 His_biosynth, Histidine biosynthesis protein. Belongs to the hisA / hisF family. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1507580 | 1508365 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1263|hisF
MYSGNGLAVRVIPCLDVYCGRVVKGVNFKNLRDAGDLVELAAAYDAEGADELAFLDVTASSSGRATMLEVVRCTAEQVFIPLMVGGGVRTVADVDVLLRAGADKVAVNTAAIARPELLADMAGQFGSQCIVLSVDARTVPTGSARTPSGWEATTHGGYRGTGIDAVEWAARGADLGVGEILLNSMDADGTKAGFDLAMLRAVRAAVTVPVIASGGAGAIEHFVPAVTAGADAVLAASVFHFRELTIGQVKDAMAAAGIAVR
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