Gene ML1264 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namehisI
Gene length348 bp
IdentifierML1264
Location 1508362 bp
Protein summary information
Molecular mass12582.0 Da
Isoelectric point4.81
Protein length116 amino acids
Structural information
PFAMPF01502
Orthologs
M. tuberculosis H37RvRv1606
M. lepromatosis Mx1-22AMLPM_1264
Cross-references
UniProtQ9X7C3
Gene OntologyHistidine biosynthetic process, Phosphoribosyl-amp cyclohydrolase activity, Cytoplasm
Enzyme Classification3.5.4.19
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable phosphoribosyl-AMP 1,6 cyclohydrolase HisI
CommentsML1264, len: 115 aa. Probable hisI, phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19). Highly similar to many phosphoribosyl-AMP cyclohydrolases involved in histidine biosynthesis including: Mycobacterium tuberculosis Rv1606 SW:HIS3_MYCTU (O53909) (115 aa), Fasta scores: E(): 0, 84.3% identity in 115 aa overlap and Bacillus subtilis SW:HIS2_BACSU (O34912) (209 aa), Fasta scores: E(): 6.3e-18, 50.0% identity in 98 aa overlap. Contains Pfam match to entry PF01502 PRA-CH, Phosphoribosyl-AMP cyclohydrolase.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS15083621508709+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1264|hisI
MTLDPDIAVRLKRNAEGLFTAVVQERSSGDVLMVAWMDDQALARTLETREANYYSRSRAEQWIKGSTSGNTQHVHSVRLDCDGDTVLLTVDQVGGACHTGAHSCFDSAMLLAPQD
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