Gene ML1269
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Possibly involved in biosynthesis of tryptophan (at the first step). Supposed tetramer of two components I and two components II: component I (ML1269|trpE) catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II (ML0015|trpG) provides glutamine aminotranferase activity. Possibly participates in the tryptophan-dependent indole-3-acetic acid production [Catalytic activity: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate]. |
| Product | Probable anthranilate synthase component I TrpE (GLUTAMINE AMIDOTRANSFERASE) |
| Comments | ML1269, len: 529 aa. Probable trpE, anthranilate synthase component I (EC 4.1.3.27). Highly similar to many anthranilate synthase component I family proteins involved in tryptophan biosynthesis e.g. Mycobacterium tuberculosis Rv1609 SW:TRPE_MYCTU (O06127) (516 aa), Fasta scores: E(): 0, 88.0% identity in 508 aa overlap and Pseudomonas putida SW:TRPE_PSEPU (P20579) (493 aa), Fasta scores: E(): 0, 44.4% identity in 504 aa overlap. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1512142 | 1513731 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1269|trpE
VHAHLAATTSREDFRQLAVDHRVVPVTRKVLADSETPLSAYRKLAANRPSTFLLESAENGRSWSQWSFIGVGAPSALTIRDGEAVWLGTVPQDAPTGGDPLHVLQATLELLATAAMPGLPPLSSGMVGFFAYDMVRRLERLPELALNDLQLPDMLLLLATDVAAVDHHEGTITLIANAVNWNGTDERVDQAYDDAIARLDVMTAALGQPLPSTIATFSRPDPRRRAQCTIEEYGAIVDHLVDQIAAGEAFQVVPSQRFEVDTDVDPIDVYRMLRVTNPSPYMYLLHVPNSDGATGFSIVGSSPEALVTVKDGRVTTHPIAGTRWRGQTEEEDQLLEKELLADEKERAEHLMLVDLGRNDLGRVCTPGTVRVEDYSHVERYSHVMHMVSTVTGLLGEGRTALDAVTACFPAGTLSGAPKVRSMELIEEVEKTRRGLYGGVVGYLDFAGNADFAIAIRTALMRDGIAYVQAGGGVVADSNGPYEYIEASNKARAVLNAIAAAETLTSLDFGVALAPGRVAARGEAGNQGRL
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