Gene ML1271 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nametrpC
Gene length819 bp
IdentifierML1271
Location 1514503 bp
Protein summary information
Molecular mass28145.4 Da
Isoelectric point5.01
Protein length273 amino acids
Structural information
PFAMPF00218
Orthologs
M. tuberculosis H37RvRv1611
M. lepromatosis Mx1-22AMLPM_1271
Cross-references
UniProtQ9X7C7
Gene OntologyTryptophan biosynthetic process, Indole-3-glycerol-phosphate synthase activity
Enzyme Classification4.1.1.48
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable indole-3-glycerol phosphate synthase TrpC
CommentsML1271, len: 272 aa. Probable trpC, indole-3-glycerol phosphate synthase (EC 4.1.1.48). Highly similar to many indole-3-glycerol phosphate synthases involved in tryptophan biosynthesis e.g. Mycobacterium tuberculosis Rv1611 SW:TRPC_MYCTU (O06129) (272 aa), Fasta scores: E(): 0, 90.8% identity in 272 aa overlap and Streptomyces coelicolor SW:TRC1_STRCO (O68814) (269 aa), Fasta scores: E(): 0, 64.1% identity in 262 aa overlap. Contains Pfam match to entry PF00218 IGPS, Indole-3-glycerol phosphate synthases. Contains PS00614 Indole-3-glycerol phosphate synthase signature.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS15145031515321+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1271|trpC
MCPATVLDSILKGVRADVAAREACISLSEIKAAAAAAPAPLDAMAALREPGIGVIAEVKRASPSVGSLATIADPAKLAQAYEDGGARIISVLTEERRFNGSLDDLDAVRAAVSVPVLRKDFVVQPYQIHEARAHGADMLLLIVAALDQSALMSMLDRTESLGMIALVEVRTEQEADRALKAGAKVIGVNARDLMTLEVDRDCFSRIAPGLPSNVIRIAESGVRGPADLLAYAGAGADAVLVGEGLVKSGDPRAAVADLVTAGTHPSCPKPAR
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