Gene ML1272
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | tryptophan biosynthesis pathway (fifth last step). THE BETA SUBUNIT IS RESPONSIBLE FOR THE SYNTHESIS OF L-TRYPTOPHAN FROM INDOLE AND L-SERINE. [CATALYTIC ACTIVITY : L-SERINE + 1-(INDOL-3-YL)GLYCEROL 3-PHOSPHATE = L-TRYPTOPHAN + GLYCERALDEHYDE 3-PHOSPHATE + H(2)O] |
| Product | Probable tryptophan synthase, beta subunit TrpB |
| Comments | ML1272, len: 417 aa. Probable trpB, tryptophan synthase, beta subunit (EC 4.2.1.20). Highly similar to many tryptophan synthases [beta chain] involved in tryptophan biosynthesis e.g. Mycobacterium tuberculosis Rv1612 SW:TRPB_MYCTU (O08376) (410 aa), Fasta scores: E(): 0, 86.7% identity in 407 aa overlap and Streptomyces coelicolor SW:TRPB_STRCO (O05625) (427 aa), Fasta scores: E(): 0, 65.2% identity in 405 aa overlap. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme. Contains PS00168 Tryptophan synthase beta chain pyridoxal-phosphate attachment site. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1515385 | 1516638 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1272|trpB
VMPNLSCFSVAISEPTCHDPDSGGHFGGPDGYGGRYVPEALMAVIEEVTAAYEKERVNQDFLDLLDKLQANYAGRPSPLYEATRLSEYAGSVRIFLKREDLNHTGSHKINNVLGQTLLAQRMGKTRVIAETGAGQHGVATATACALFGLDCVIYMGALDTARQALNVARMRLLGAEVVSVETGSRTLKDAINDAFRDWVTNADNTYYCFGTASGPHPFPTMVRDLQRVIGLETRRQIQYQAGRLPDAVTACIGGGSNAIGIFHAFLDDPGVRLVGFEAAGDGVETGRHAATLTGGLPGAFQGTFSYLLQDEDGQTIESHSIAAGLDYPGVGPEHAWLRETGRAEYQPITDSEAIEAFRLLCRTEGILPALESAHAVAGALKLASEIGKGAVIVVNLSGRGDKDIEAAAKWFGLLGTR
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