Gene ML1273
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | tryptophan biosynthesis pathway (fifth - last step). THE ALPHA SUBUNIT IS RESPONSIBLE FOR THE ALDOL CLEAVAGE OF INDOLEGLYCEROL PHOSPHATE TO INDOLE AND GLYCERALDEHYDE 3- PHOSPHATE. [CATALYTIC ACTIVITY: L-SERINE + 1-(INDOL-3-YL)GLYCEROL 3-PHOSPHATE = L-TRYPTOPHAN + GLYCERALDEHYDE 3-PHOSPHATE + H(2)O.] |
| Product | Probable tryptophan synthase, alpha subunit TrpA |
| Comments | ML1273, len: 270 aa. Probable trpA, tryptophan synthase, alpha subunit (EC 4.2.1.20). Highly similar to many tryptophan synthases [alpha chain] involved in tryptophan biosynthesis e.g. Mycobacterium tuberculosis Rv1613 SW:TRPA_MYCTU (O06130) (270 aa), Fasta scores: E(): 0, 86.0% identity in 265 aa overlap and Streptomyces coelicolor SW:TRPA_STRCO (O68816) (271 aa), Fasta scores: E(): 0, 46.4% identity in 261 aa overlap. Contains Pfam match to entry PF00290 trp_syntA, Tryptophan synthase alpha chain. Belongs to the trpA family. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1516635 | 1517447 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1273|trpA
MMVLEQSETSRLGPVFDSCRADNRAALIGYLPTGYPDVPTSVDAMIELVESGCDIIEVGVPYSDPGMDGPTIARATEVALRGGVRVRDTLAAVEAISQAGGRAVVMTYWNPVLRYGVCAFARDLESAGGHGLVTPDLIPDEARQWIAASEKHRLDRIFLVAPSSTPHRLVTTVGASRGFVYAVSVMGVTGARDAVSQVVPELVARVKAVSDIAVGVGLGVRSREQAAQIGGYADGVIVGSALVSALGDGLPRLRALAEELAAGVRQRTFM
Bibliography
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