Gene ML1274 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namelgt
Gene length993 bp
IdentifierML1274
Location 1517444 bp
Protein summary information
Molecular mass36253.6 Da
Isoelectric point6.25
Protein length331 amino acids
Structural information
PFAMPF01790
Orthologs
M. tuberculosis H37RvRv1614
M. lepromatosis Mx1-22AMLPM_1274
Cross-references
UniProtQ9CC52
Gene OntologyLipoprotein biosynthetic process, Phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity, Plasma membrane, Protein lipoylation, Integral to membrane
Enzyme Classification2.4.99.-
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPossible prolipoprotein diacylglyceryl transferases Lgt
CommentsML1274, len: 330 aa. Possible lgt, prolipoprotein diacylglyceryl transferase (EC 2.4.99.-). Similar to many prolipoprotein diacylglyceryl transferases constituting the first step in lipoprotein biosynthesis e.g. Staphylococcus aureus SW:LGT_STAAU (P52282) (279 aa), Fasta scores: E(): 3.3e-12, 30.6% identity in 258 aa overlap and Mycobacterium tuberculosis Rv1614 TR:O06131 (EMBL:Z95554) (468 aa), Fasta scores: E(): 0, 75.5% identity in 322 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01790 LGT, Prolipoprotein diacylglyceryl transferase.
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS15174441518436+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1274|lgt
VTRMLPGYFPSPPRGVWHLGPLPIRAYALLIILGIVAALVVGGRCWEARGGERDVTYDIALWAVPFGLVGGRLYHLATDWRTYFGQNGAGLGAALRIWDGGLGIWGAVALGCVGAWLGCRRHRIPLPAFGDALAPGIILAQAIGRLGNYFNQELYGRETTMPWGLEVFYRRDPAGYMDPHSLDGVSTGQLAFVVQPTFLYELIWNVLVFFALIYVDRWFTLGHGRLFATYVAAYCIGRFCVELLRDDAATHIAGIRINSFTSTFVFIGAVVYIILAPKGREEPENLCRAEYVAREIPEPESATERATVASTYATTTAVPVSADEEFAETN
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