Gene ML1277 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namepykA
Gene length1419 bp
IdentifierML1277
Location 1519744 bp
Protein summary information
Molecular mass50621.9 Da
Isoelectric point6.03
Protein length473 amino acids
Structural information
PFAMPF00224, PF02887
Orthologs
M. tuberculosis H37RvRv1617
M. lepromatosis Mx1-22AMLPM_1277
Cross-references
UniProtQ9CC49
Gene OntologyMagnesium ion binding, Potassium ion binding, Pyruvate kinase activity, Glycolysis
Enzyme Classification2.7.1.40
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable pyruvate kinase PykA
CommentsML1277, len: 472 aa. Probable pyruvate kinase (EC 2.7.1.40). Highly similar to many pyruvate kinases including: Mycobacterium tuberculosis Rv1617 SW:KPYK_MYCTU (O06134) (472 aa), Fasta scores: E(): 0, 90.7% identity in 472 aa overlap and Corynebacterium glutamicum SW:KPYK_CORGL (Q46078) (475 aa), Fasta scores: E(): 0, 71.8% identity in 468 aa overlap. Contains Pfam match to entry PF00224 PK, Pyruvate kinase. Contains PS00110 Pyruvate kinase active site signature.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS15197441521162+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1277|pykA
VTRRGKIVCTLGPATQSDELIRALVEAGMDVARMNFSHGDYSDHKAVYDRVRVASDATGRAVGVLADLQGPKIRLGRFATGSTYWADGETVRITVADCHGSHDRVSTTYKNLARDAVVGDRVLVDDGKVGLVVSAIDGDDVVCTVTEGGPVSNNKGMSLPGMHVSAPALSDKDIEDLTFALNLGADLVALSFVRSPSDVELVHKAMDRVGRRVPVIAKLEKPEAVDNLEAIVLAFDAIMVARGDLGVELPLEEVPLVQKRAIQMARENAKPVIVATQMLDSMIENSRPTRAEASDVANAVLDGADALMLSEETSVGKYPLAAVKTMSRIVCAVEENSTAAPPLTHVPRTKRGVISYAARDIGERLDAKALVAFTQSGDTVRRLARLHTPLPLLAFTAWPEVRSQLAMTWGTETFLVPKMLSTDGMIRQVDKSLLELGRYKRGDLVVIVAGTPPGTVGSTNLIHVHRIGEDDV
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