Gene ML1293c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namepyrD
Gene length1074 bp
IdentifierML1293c
Location 1543268 bp
Protein summary information
Molecular mass37847.6 Da
Isoelectric point9.58
Protein length358 amino acids
Structural information
PFAMPF01180
Orthologs
M. tuberculosis H37RvRv2139
M. lepromatosis Mx1-22AMLPM_1293
Cross-references
UniProtP46727
Gene OntologyUmp biosynthetic process, Dihydroorotate oxidase activity, Oxidation-reduction process, Plasma membrane, 'de novo' pyrimidine nucleobase biosynthetic process
Enzyme Classification1.3.3.1
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable dihydroorotate dehydrogenase PyrD
CommentsML1293c, len: 357 aa. Probable pyrD, dihydroorotate dehydrogenase (EC 1.3.3.1). Highly similar to many dihydroorotate dehydrogenases involved in pyrimidine biosynthesis, including: Escherichia coli PyrD SW:PYRD_ECOLI (P05021) (336 aa), Fasta scores: E(): 0, 42.3% identity in 333 aa overlap and Mycobacterium tuberculosis PyrD Rv2139 SW:PYRD_MYCTU (O06236) (357 aa), Fasta scores: E(): 0, 80.9% identity in 351 aa overlap. Contains Pfam match to entry PF01180 DHOdehase, Dihydroorotate dehydrogenase. Contains PS00912 Dihydroorotate dehydrogenase signature 2. Contains PS00911 Dihydroorotate dehydrogenase signature 1.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS15432681544341-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1293c|pyrD
VMYRVVRRLLFLTPPERIHTLVFAMLRCVTSIAVLRRLLRWVLGPTDPVLASTVFGVRFPGPLGLAAGFDKDGMGLLAWGALGFGYAEVGTVTAYPQPGNPAPRMFRLPADRALLNRMGFNNNGAGALAIQLAHHRPEVPIGVNISKTKATPASHTVDDYRASARLVGPLASYLVVNVSSPNTPGLRDLQAVESLRAILLGVLAETSVPVLVKIAPDISDSEIDDITDLAVELRLAGIVATNTTVSRDCLVTPGIDALGAGGISGPPVARRAVEVLRRLYGRVGDRLVLISVGGIETADDAWDRITAGASLLQGYTGFIYGGGFWPKHIHDGIARRLHDGGFASLRDAVGSATAKSE
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