Gene ML1307 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namemetH
Gene length3621 bp
IdentifierML1307
Location 1556855 bp
Protein summary information
Molecular mass132392.0 Da
Isoelectric point4.82
Protein length1207 amino acids
Structural information
PFAMPF00809, PF02310, PF02574, PF02607, PF02965
Orthologs
M. tuberculosis H37RvRv2124c
M. lepromatosis Mx1-22AMLPM_1307
Cross-references
UniProtQ49775
Gene OntologyCobalt ion binding, Dihydropteroate synthase activity, Folic acid-containing compound biosynthetic process, Homocysteine s-methyltransferase activity, Intracellular, Methionine biosynthetic process, Methionine synthase activity, Zinc ion binding, Cobalamin binding
Enzyme Classification2.1.1.13
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable 5-methyltetrahydrofolate--homocystein methyltransferase MetH (Methionine synthase, vitamin-B12 dependent isozyme) (MS)
CommentsML1307, len: 1206 aa. Probable 5-methyltetrahydrofolate--homocystein methyltransferase (EC 2.1.1.13). Highly similar to many 5-methyltetrahydrofolate--homocysteine methyltransferases involved in methionine biosynthesis, including: Escherichia coli MetH SW:METH_ECOLI (P13009) (1226 aa), Fasta scores: E(): 0, 31.6% identity in 1233 aa overlap and Mycobacterium tuberculosis Rv2124c SW:METH_MYCTU (O33259) (1192 aa), Fasta scores: E(): 0, 88.3% identity in 1204 aa overlap.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS15568551560475+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1307|metH
MRVTAANQHQYDTDLLETLAQRVMVGDGAMGTQLQDAELTLDDFRGLEGCNEILNETRPDVLETIHRRYFEAGADLVETNTFGCNLSNLGDYDIADKIRDLSQRGTVIARRVADELTTPDHKRYVLGSMGPGTKLPTLGHTEYRVVRDAYTESALGMLDGGADAVLVETCQDLLQLKAAVLGSRRAMTQAGRHIPVFVHVTVETTGTMLLGSEIGAALAAVEPLGVDMIGLNCATGPAEMSEHLRHLSKHARIPVSVMPNAGLPVLGAKGAEYPLQPDELAEALAGFIAEFGLSLVGGCCGTTPDHIREVAAAVARCNDGTVPRGERHVTYEPSVSSLYTAIPFAQKPSVLMIGERTNANGSKVFREAMIAEDYQKCLDIAKDQTRGGAHLLDLCVDYVGRNGVADMKALAGRLATVSTLPIMLDSTEIPVLQAGLEHLGGRCVINSVNYEDGDGPESRFVKTMELVAEHGAAVVALTIDEQGQARTVEKKVEVAERLINDITSNWGVDKSAILIDCLTFTIATGQEESRKDGIETIDAIRELKKRHPAVQTTLGLSNISFGLNPSARQVLNSVFLHECQEAGLDSAIVHASKILPINRIPEEQRQAALDLVYDRRREGYDPLQKLMWLFKGVSSPSSKETREAELAKLPLFDRLAQRIVDGERNGLDVDLDEAMTQKPPLAIINENLLDGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMEKSDCDFGKGLAKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNLGIKQPITNILEVAEDKSADVVGMSGLLVKSTVIMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEVYEGEVHYARDAFEGLKLMDTIMSAKRGEALAPGSPESLAAEADRNKETERKARHERSKRIAVQRKAAEEPVEVPERSDVPSDVEVPAPPFWGSRIIKGLAVADYTGFLDERALFLGQWGLRGVRGGAGPSYEDLVQTEGRPRLRYWLDRLSTYGVLAYAAVVYGYFPAVSEDNDIVVLAEPRPDAEQRYRFTFPRQQRGRFLCIADFIRSRDLATERSEVDVLPFQLVTMGQPIADFVGELFVSNSYRDYLEVHGIGVQLTEALAEYWHRRIREELKFSGNRTMSADDPEAVEDYFKLGYRGARFAFGYGACPDLEDRIKMMELLQPERIGVTISEELQLHPEQSTDAFVLHHPAAKYFNV
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