Gene ML1309 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namehisE
Gene length282 bp
IdentifierML1309
Location 1561970 bp
Protein summary information
Molecular mass10382.8 Da
Isoelectric point4.69
Protein length94 amino acids
Structural information
PFAMPF01503
Orthologs
M. tuberculosis H37RvRv2122c
M. lepromatosis Mx1-22AMLPM_1309
Cross-references
UniProtQ49786
Gene OntologyCytoplasm, Histidine biosynthetic process, Phosphoribosyl-atp diphosphatase activity, Atp binding
Enzyme Classification3.6.1.31
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable phosphoribosyl-AMP pyrophosphatase HisE
CommentsML1309, len: 93 aa. Probable phosphoribosyl-AMP pyrophosphatase (EC 3.6.1.31). Highly similar to several phosphoribosyl-ATP pyrophosphatases involved in histidine biosynthesis, including: Sulfolobus solfataricus HisE SW:HIS2_SULSO (O33776) (94 aa), Fasta scores: E(): 0.00013, 32.5% identity in 83 aa overlap and Mycobacterium tuberculosis Rv2122c|HIS2_MYCTU (O33257) (93 aa), Fasta scores: E(): 2.5e-31, 86.0% identity in 93 aa overlap. Contains Pfam match to entry PF01503 PRA-PH, Phosphoribosyl-ATP pyrophosphohydrolase.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS15619701562251+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1309|hisE
VKQSLAVKTFEDLFAELSERARTRPTDSATVASLDGGIHALGKKILEEAGEVWLAAEHEPKEVLAEEISQLLYWTQVLMISRGLSLDDVYRKL
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