Gene ML1310 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namehisG
Gene length870 bp
IdentifierML1310
Location 1562248 bp
Protein summary information
Molecular mass31079.4 Da
Isoelectric point4.93
Protein length290 amino acids
Structural information
PFAMPF01634, PF08029
Orthologs
M. tuberculosis H37RvRv2121c
M. lepromatosis Mx1-22AMLPM_1310
Cross-references
UniProtQ49776
Gene OntologyAtp phosphoribosyltransferase activity, Cytoplasm, Histidine biosynthetic process, Magnesium ion binding, Atp binding
Enzyme Classification2.4.2.17
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable ATP phosphoribosyltransferase HisG
CommentsML1310, len: 289 aa. Probable hisG, ATP phosphoribosyltransferase (EC 2.4.2.17). Highly similar to many ATP phosphoribosyltransferases involved in histidine biosynthesis, including: Sulfolobus solfataricus HisG SW:HIS1_SULSO (O33771) (290 aa), Fasta scores: E(): 4e-20, 32.0% identity in 291 aa overlap and Mycobacterium tuberculosis Rv2121c SW:HIS1_MYCTU (O33256) (284 aa), Fasta scores: E(): 0, 87.8% identity in 287 aa overlap. Contains Pfam match to entry PF01503 PRA-PH, Phosphoribosyl-ATP pyrophosphohydrolase. Contains Pfam match to entry PF01634 HisG, ATP phosphoribosyltransferase. Contains PS01316 ATP phosphoribosyltransferase signature.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS15622481563117+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1310|hisG
VSMLRVAVPNKGALSEPATEILAEAGYRRRTDPKDLTVVDPVNRVEFFFLRPKDIAIYVGSGDLDFGITGRDLVHDSDASVCERLALGFGSSSFRYAGPAGRDWTTSDLAGKRIATAYSNLVRKDLVAKGIEATVIRLDGAVEISVQLGVADVIADVVGSGRTLSLHDLVAFGEPLCDSEAVLIERGDRGSLDHHETVAARDQLVARVQGVVFGQQYLMLDYDCPRSVLDKATLITSGLESPTIAPLAEPGWVAIRALVPRRDINGIMDELAAIGAKAILASDIRFCRF
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