Gene ML1333 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namehelY
Gene length2763 bp
IdentifierML1333
Location 1584499 bp
Protein summary information
Molecular mass100863.0 Da
Isoelectric point7.29
Protein length921 amino acids
Structural information
PFAMPF00270, PF00271, PF08148
Orthologs
M. tuberculosis H37RvRv2092c
M. lepromatosis Mx1-22AMLPM_1333
Cross-references
UniProtQ9ZBD8
Gene OntologyAtp-dependent helicase activity, Nucleic acid binding, Atp binding
Enzyme Classification3.6.1.-
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE ATP-DEPENDENT DNA HELICASE HELY
CommentsML1333, len: 920 aa. Probable helY, DNA helicase (EC 3.6.1.-). Highly similar to many proposed Prokaryotic and Eukaryotic helicases including: Mycobacterium tuberculosis Rv2092c SW:HELY_MYCTU (Q10701) (906 aa), Fasta scores: E(): 0, 82.5% identity in 922 aa overlap and Saccharomyces cerevisiae ATP-dependent RNA helicase Dob1 SW:MTR4_YEAST (P47047) (1073 aa), Fasta scores: E(): 0, 27.2% identity in 972 aa overlap. Contains Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase. Contains PS00017 ATP/GTP-binding site motif A (P-loop).
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS15844991587261+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1333|helY
MTDLAELARFTAELPFSLDDFQQRACAALERGHGVLVCAPTGAGKTVVGEFAVHLALAAGGKCFYTTPLKALSNQKYTDLTARYGRNRIGLLTGDQSVNGDSPVVVMTTEVLRNMLYADSFALQGLSHVVMDEVHFIADRMRGPVWEEVILHLPDDVRMVSLSATVSNAEEFGGWVQTVRGDTTVVVDEHRPVPLWQHVLVGKRLFDLFDYDSNVDQSPVNPNLLRHIAHCREADRMSDWRNPRRRAGRGSGVRPRFYRSLARPEVIAILDAEGLLPAITFVFSRFGCDAAVQQCLRSPLRLTSEEERAQIAEVIDHRCGDLADADLAVLGYYEWREGLLRGLAAHHAGMLPAFRHAVEELFTAGLVKAVFATETLALGINMPARTVVLERLVKFNGKQHVPLTPGEYTQLTGRAGRRGIDVEGHAVVIWHPSEDTSGPSAVAGLASARTFPLRSSFVPSYNMTINLVHWMSPERAHALLEQSFAQYQADRSVVGLVRGIERCTQVLGDISSELGGPDAPILEYARLRARIAEMERAQSFVFRLQRKQAANDVLAALRRGDIITITHGRHGGLAVVLESARDSSNPRPLVLTEHRWAGRISSADYMGAAAPVGSMTLPKRVEHRQQRVRRDLASALRSAATRLSVPDIGDGVDGDKIGFNDGVLHDPELASLRAQLRRHRSNNAPGLDTQLQQAERYLRIERYNAQLQRKVAAATNSLARTFDRIVGLLIERDFIRGPADDPQVTDDGRLLARIYSESDLLVAECLRTGAWAGLRPAELAAVVSAVLYETRGDDGPGGPVDAEAPTPRLRQALQHTSRLSATLRADEQRHRIALSREPDDGFVGVIYCWARTGDLAAVLAAADASGNGAPLSAGDFVRWCRQVLDLLDQLRNAAPEPDLRATAKRAINDVRRGVVAVDAG
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