Gene ML1352 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nametyrS
Gene length1281 bp
IdentifierML1352
Location 1612179 bp
Protein summary information
Molecular mass47017.3 Da
Isoelectric point6.87
Protein length427 amino acids
Structural information
PFAMPF00579, PF01479
Orthologs
M. tuberculosis H37RvRv1689
M. lepromatosis Mx1-22AMLPM_1352
Cross-references
UniProtQ49900
Gene OntologyRna binding, Cytoplasm, Tyrosine-trna ligase activity, Tyrosyl-trna aminoacylation, Atp binding
Enzyme Classification6.1.1.1
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable Tyrosyl-tRNA synthase TyrS (TYRRS)
CommentsML1352, len: 426 aa. Probable Tyrosyl-tRNA synthase (EC 6.1.1.1). Highly similar to many tyrosyl-tRNA synthetases including: Bacillus stearothermophilus SW:SYY_BACST (P00952) (419 aa), Fasta scores: E(): 0, 50.2% identity in 416 aa overlap and Mycobacterium tuberculosis Rv1689 SW:SYY_MYCTU (O33191) (424 aa), Fasta scores: E(): 0, 83.6% identity in 426 aa overlap. Contains Pfam match to entry PF00579 tRNA-synt_1b, tRNA synthetases class I (W and Y). Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS16121791613459+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1352|tyrS
VSSSILNELGWRGLVAQSTDLDALADELRRGPMTVYAGFDPTAPSLHVGHLVPLLVLRRFQRAGHRPIVLAGGATGMIGDPRDIGERTLNEAYTVAEWAERIRGQLERFVEFDDVAKSRNGAIVVNNLEWTSPMSAIEFLRDVGKHFSINLMLDRDTIRRRLNGQGISYTEFSYMLLQANDYAELHQRHGCALQIGGSDQWGNIIAGVRLVRQKLGATVHALTVPLVTAADGAKLGKSTGGGSLWLDPEMTSPYAWYQYFINTSDADVIRYLRWFTFLLPEELVELEQTTVSRPQERAAQRRLATELTVLVHGAAATQAVEHASRALFGQGELARLDEATLATALRETVVAELKPGNPDGIVDLLVASGLSPSRGAARRTIDEGGVLVNNIRIQSEEWTPRTSDFLHGRWLVLRRGKRNIAGIERV
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