Gene ML1371 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namecmk
Gene length672 bp
IdentifierML1371
Location 1631209 bp
Protein summary information
Molecular mass24078.2 Da
Isoelectric point5.14
Protein length224 amino acids
Structural information
PFAMPF02224
Orthologs
M. tuberculosis H37RvRv1712
M. lepromatosis Mx1-22AMLPM_1371
Cross-references
UniProtQ49885
Gene OntologyCytidylate kinase activity, Cytoplasm, Pyrimidine nucleotide metabolic process, Atp binding
Enzyme Classification2.7.4.14
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable Cytidylate kinase Cmk (CMP kinase) (Cytidine monophosphate kinase) (CK)
CommentsML1371, len: 223 aa. Probable cmk, Cytidylate kinase (EC 2.7.4.14). Highly similar to several cytidylate kinases including: Bacillus subtilis SW:KCY_BACSU (P38493) (224 aa), Fasta scores: E(): 1.9e-28, 42.7% identity in 218 aa overlap and Mycobacterium tuberculosis Rv1712 TR:O33211 (EMBL:Z98268) (230 aa), Fasta scores: E(): 0, 74.8% identity in 222 aa overlap. Contains Pfam match to entry PF02224 Cytidylate_kin, Cytidylate kinase. Contains PS00017 ATP/GTP-binding site motif A (P-loop).
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS16312091631880+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1371|cmk
VTDIVVAIDGPAGTGKSSVSRGLARELGARYLDTGAMYRMMTLAVLRAGIDPADAAAIGESVWKVQMLSDHDRYFLGGEDVSSEIRTEEVTQAVSAVSAIPAVRVRLVDLQRQMAEGRGSVVVEGRDIGTVVLPDAPVKIFLTASPETRARRRNDQNVASGSADDYDRVLAEVRRRDHLDSTRAVSPLYVAQDAMIVDTSKMAEAEVIAHLMDLVKQRSGAVW
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