Gene ML1381c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namepolA
Gene length2736 bp
IdentifierML1381c
Location 1648224 bp
Protein summary information
Molecular mass99759.8 Da
Isoelectric point4.88
Protein length912 amino acids
Structural information
PFAMPF00476, PF01367, PF02739
Orthologs
M. tuberculosis H37RvRv1629
M. lepromatosis Mx1-22AMLPM_1381
Cross-references
UniProtP46835
Gene Ontology5'-3' exonuclease activity, Dna binding, Dna repair, Dna replication, Dna-directed dna polymerase activity, Intracellular, 3'-5' exonuclease activity
Enzyme Classification2.7.7.7
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE DNA POLYMERASE I POLA
CommentsML1381c, len: 911 aa. Probable polA, DNA polymerase I (EC 2.7.7.7). Highly similar to DNA polymerase I (EC 2.7.7.7) (PolI) from many bacteria including: Escherichia coli SW:DPO1_ECOLI (P00582) (928 aa), Fasta scores: E(): 0, 36.4% identity in 945 aa overlap and Mycobacterium tuberculosis Rv1629 SW:DPO1_MYCTU (Q07700) (904 aa), Fasta scores: E(): 0, 85.2% identity in 901 aa overlap. Previously sequenced SW:DPO1_MYCLE (P46835) (911 aa), Fasta scores: E(): 0, 99.9% identity in 911 aa overlap. Contains Pfam match to entry PF01367 5_3_exonuclease, 5'-3' exonuclease. Contains Pfam match to entry PF00476 DNA_pol_A, DNA polymerase family A. Contains PS00447 DNA polymerase family A signature.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS16482241650959-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1381c|polA
VSAAMTAEVCEDHTKPMLMLLDGNSLAFRAFYALPTENFKTRGGLTTNAVYGFTAMLINLLREEAPTHIAAAFDVSRKTFRSECYAGYKANRSSIPAEFHGQIDITKEVLGALGITVFAEAGFEADDLIATLATQAENEGYRVLVVTGDRDALQLVSNDVTVLYPRKGVSELTRFTPEAVIEKYGVTPAQYPDLAALRGDPSDNLPGIPGVGEKTAAKWIVDYGSLQGLVDNVESVRGKVGEALRTHLASVVRNRELTELVKDVPLVQTSDTLRLQPWDRDRIHRLFDNLEFRVLRDRLFEALAAAGERVPEVDEGFDVRGGLLESGTVGRWLAKHADDGRRSGLAIVGTHLPHGGDATALAVAAADGNGGYIDTAMLTPDDDDALAAWLADPDNPKALHEAKLAMHDLAGRGWTLGGITSDTALAAYLVRPGQRSFTLDDLSLRYLRRELRAETPEQEQFSLLDNVDEVDKQAIQTLILRARAVVDLAAALDAELDLIDSTSLLGEMELPVQQVLADMEKAGIAADLRLLTELQSQFGDQIRDAAEAAYAVIGKQINLSSPKQLQVVLFEELGMPKTKRTKTGYTTDADALQSLFCKTEHPFLQHLLTHRDVTRLKVTVDGLLNAVAADGRIHTTFNQTIATTGRLSSTEPNLQNIPIRTNAGRQIRDAFVVGSENNGYTELMTADYSQIEMRIMAHLSRDEGLIEAFHTGEDLHSFVASRAFGIPIEDITPELRRRVKAMSYGLAYGLSAYGLATQLKISTEEAKLQMEQYFARFGGVRDYLMDVVEQARKDGYTSTVLGRRRYLPELDSSNRQIREAAERAALNAPIQGSAADIIKVAMIAVDKSLKQAKLASRMLLQVHDELLFEVAIGEREQIEAMVREQMGSAYPLDVPLEVSVGFGRSWGAAAH
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