Gene ML1387
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN NUCLEOTIDE EXCISION REPAIR. THE ABC EXCISION NUCLEASE IS A DNA REPAIR ENZYME THAT CATALYZES THE EXCISION REACTION OF UV-DAMAGED NUCLEOTIDE SEGMENTS PRODUCING OLIGOMERS HAVING THE MODIFIED BASE(S). UVRB STIMULATES THE ATPASE ACTIVITY OF UVRA IN THE PRESENCE OF UV-IRRADIATED DOUBLE-STRANDED DNA. IT ALSO ENHANCES THE ABILITY OF UVRA TO BIND TO UV-IRRADIATED DUPLEX DNA |
| Product | PROBABLE EXCINUCLEASE ABC (SUBUNIT B - HELICASE) UVRB |
| Comments | ML1387, len: 698 aa. Probable uvrB, excinuclease ABC subunit B. Highly similar to many excinucleases ABC (subunit B), involved in DNA repair following UV damage, including: Micrococcus luteus SW:UVRB_MICLU (P10125) (709 aa), Fasta scores: E(): 0, 71.4% identity in 700 aa overlap and Mycobacterium tuberculosis Rv1633 SW:UVRB_MYCTU (O06150) (698 aa), Fasta scores: E(): 0, 94.7% identity in 698 aa overlap. Contains Pfam match to entry PF00271 helicase_C, Helicases conserved C-terminal domain. Contains Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase. Contains Pfam match to entry PF02151 UVR, UvrB/uvrC motif. Contains PS00017 ATP/GTP-binding site motif A (P-loop). |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1661669 | 1663765 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1387|uvrB
VRVGGRFEVISPHEPAGDQPAAIDELQRRILAGERDVVLLGATGTGKSATTAWLIERLQRPTLVMAPNKTLAAQLANELRGMLPHNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDDVERLRHSATSSLLSRRDVVVVASVSCIYGLGTPQSYLDRSVELAVSNEVPRDGLLRLLVDVQYTRNDLSFTRGSFRVRGDTVEIIPSYEELAVRIEFFGDEIEALYYLHPLTGEVIRQVDSLRIFPATHYVAGPERMAQAISAIEEELAERLAEFERQGKLLEAQRLRMRTNYDIEMMRQVGFCSGIENYSRHIDGRGPGTPPATLLDYFPEDFLLVIDESHVTVPQIGGMYEGDMSRKRNLVEYGFRLPSACDNRPLTWEEFADRIGQTVYLSATPGPYELSQSGGEFVEQVIRPTGLVDPKVVVKPTKGQIDDLIGEIRKRANADQRVLVTTLTKKMAEDLTDYLLEMGIRVRYLHSEVDTLRRVELLRQLRLGDYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSARSLIQTIGRAARNVSGEVHMYADTITDSMTEAIDETERRRAKQIAYNNANGIDPQPLRKKIADILDQVYREADDTDTVQVGGSGRNVSRGRRAQSEPVRSVSVGVFEGRDTAGMPRAELADLIKDLTAQMMAAASDLQFELAARFRDEIADLKKELRGMDAAGLK
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