Gene ML1392
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN NUCLEOTIDE EXCISION REPAIR. THE ABC EXCISION NUCLEASE IS A DNA REPAIR ENZYME THAT CATALYZES THE EXCISION REACTION OF UV-DAMAGED NUCLEOTIDE SEGMENTS PRODUCING OLIGOMERS HAVING THE MODIFIED BASE(S). UVRA IS AN ATPASE AND A DNA-BINDING PROTEIN THAT PREFERENTIALLY BINDS SINGLE-STRANDED OR UV-IRRADIATED DOUBLE-STRANDED DNA. |
| Product | PROBABLE EXCINUCLEASE ABC (SUBUNIT A - DNA-BINDING ATPase) UVRA |
| Comments | ML1392, len: 969 aa. Probable excinuclease ABC subunit A> Highly similar to many excinucleases ABC (subunit A), involved in DNA repair following UV damage, including: Micrococcus luteus SW:UVRA_MICLU (P13567) (992 aa), Fasta scores: E(): 0, 69.3% identity in 966 aa overlap and Mycobacterium tuberculosis Rv1638 SW:UVRA_MYCTU (P94972) (972 aa), Fasta scores: E(): 0, 90.9% identity in 975 aa overlap. Contains 2 Pfam matches to entry PF00005 ABC_tran, ABC transporter. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop). |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1668341 | 1671250 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1392|uvrA
VADRLIVKGAREHNLRSVDLDLPRDSLIVFTGLSGSGKSSLAFDTIFAEGQRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVGTITEVYDYLRLLYARAGTPHCPICGEQISRQTPQQIVDQVLVLPEGTRFLVLAPVVRTRKGEFADLFDKLNAQGYSRVRVDDVVYPLSDPPKLKKQEKHDIEVVVDRLTVKIAAKQRLTDSVETALNLADGIVVLEFPDDHDERGHPREQCFSEKLACPNGHPLAVDDLEPRSFSFNSPYGACPECVGLGIRKEIDSDLVVPDPDRTLAEGAVAPWSAGRTAEYFTRMMAGLGEKLGFDVDTPWRKLPAKARKAILEGSDHQVHVQYHNRYGRPRSYYVDFEGVLTFLQRKMEQTESEQMKERYEGFMRNIPCPVCQGTRLKPEILAVTLAAGERGAKSIAEVCELSIADCSAFLNALILGVREQAIAGQVLKEIQSRLGFLLDVGLEYLSLSRAAATLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIETLTRLRALGNTLIVVEHDEDTIAHADWVVDIGPGAGEHGGQIVHNGTYRELLANKDSITGAYLSGRESIATPTRRRSVDRKRELTVVGAREHNLRGIDVSFPLGVLTSVTGVSGSGKSTLVNDILAAVLANRLNGARQVPGRHTRVTGLEHLDKLVRVDQSPIGRTPRSNPATYTGVFDKIRILFAATTEAKVRGYQPGRFSFNVKGGRCEACTGDGTIKIEMNFLPDVYVPCEVCQGARYNRETLEVHYKGKAISEVLDMSIEEAAEFFEPIIGINRYLRTLVDVGLGYVRLGQPAPTLSGGEAQRVKLASELQKRSTGRTIYILDEPTTGLHFDDIRKLLNVINGLVDKDNTVIVIEHNLDVIKTSDWIVDMGPEGGAQGGTVVAEGTPEDVAAVPESYTGKFLAEVVGAGCAPARTPRRRRTVTA
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