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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
ProductPossible lysyl-tRNA synthetase 2 LysX
CommentsML1393c, len: 1039 aa. Possible lysX, lysyl-tRNA synthetase 2 (EC 6.1.1.6). Similar to Mycobacterium tuberculosis Rv1640c TR:P94974 (EMBL:Z85982) (1172 aa), Fasta scores: E(): 0, 82.0% identity in 1041 aa overlap and Q825Z7 Putative lysyl-tRNA synthetase from Streptomyces avermitilis (1093 aa), fasta scores: E(): 2.3e-176, (55.673% identity in 1040 aa overlap). The C-terminal region of the predicted product of this CDS is highly similar to many other lysyl-tRNA synthetases including Haemophilus influenzae SW:SYK_HAEIN (P43825) (502 aa), Fasta scores: E(): 0, 40.1% identity in 504 aa overlap. The N-terminus is similar to several proposed membrane proteins e.g. Streptomyces coelicolor TR:O69916 (EMBL:AL023861) (589 aa), Fasta scores: E(): 0, 47.8% identity in 510 aa overlap. Also similar to ML0233 from M. leprae. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00152 tRNA-synt_2, tRNA synthetases class II (D, K and N). Contains PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS16719271675046-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium leprae TN|ML1393c|lysX
VLALLAAALTTRKRIAWLLLLGNMVLAAVLNAVDMAANGNTPAETFGENLGFAVHVVAILLLVLSYREFWAKVRRGALFKAAAVLVAGDVIGILLSLGLVELFPGSLARQDRLPYVANRVVGFALADPDLFSGKPHVLLNAIFGLFGALALIMATIVLFQSQRADNALTGEDESAIRGLLELYGKNDSLGYFATRRDKSVIFAHNGRAAITYRVEIGVCLASGDPVGDPGAWPQAVDAWLELCQTYGWAPGVMGASSQGAQVFRRAGFNAIELGDEAILRTAVYKLSGPDMRGVRQAVTRARRAGLTVRIRRHSDISANEMADTIARADAWRDTEFERGFSMALGRLGDPADSDCLLVEAVDRDDHVVAILSLVPWGTTGVSLDVMRRSPQSPNGTIELMVSELALKGETLGIARISLNFTMFRAAFEQGAQLGAGPIARLWRGLLLFFSRWWQLETLYRSNIKYLPDWVPRYACYEDARLIPRVGVASVIAEGFLVLPFSRRGRVHTGHHPAVPARLAESGLLHHDGSTPDVSGLQTADVDLEVANSRIPEQVRVRLAKLKTLQLNGIDAYPVGHPPSHTVAQALDADDEGTVSISGRILRIRDYGGVLFAHVRDWSGEIQVLLDNLVLECCCIADFTAAIDLGDIVEMTGNMGFSKNGTRSLIVRNWRLIGKCLRPLPNKWKGLTDPEARVRTRYVDLAVNTESRNLIMARSCVLRSVREMLFAKGFVEVETPILQQIHGGATARPFATRINTYDMDLFLRIAPELYLKRLCIGGVERVFELGRAFRNEGVDFSHNPEFTLLEAYQAHADYLMWIDGCRELIQNAAEAANGTQTLMRPRIEGASGTANHLEPIDISGVWPVKTVYEAVSEALGECVDTSTELATLRKLSDAAHIPYWPHWDTGAVVLKLYEHLVENRTDQPTFYIDFPTSVSPLTRPHRSKPGVAERWDLVAWGIELGTAYSELTDPVEQRRRLHEQSLLAVGGNPEAMELDEDFLQAMEYAMPPTGGLGMGIDRLVMLITGRSIRETLPFPLAKPH
      
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