Gene ML1393c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Possible lysyl-tRNA synthetase 2 LysX |
| Comments | ML1393c, len: 1039 aa. Possible lysX, lysyl-tRNA synthetase 2 (EC 6.1.1.6). Similar to Mycobacterium tuberculosis Rv1640c TR:P94974 (EMBL:Z85982) (1172 aa), Fasta scores: E(): 0, 82.0% identity in 1041 aa overlap and Q825Z7 Putative lysyl-tRNA synthetase from Streptomyces avermitilis (1093 aa), fasta scores: E(): 2.3e-176, (55.673% identity in 1040 aa overlap). The C-terminal region of the predicted product of this CDS is highly similar to many other lysyl-tRNA synthetases including Haemophilus influenzae SW:SYK_HAEIN (P43825) (502 aa), Fasta scores: E(): 0, 40.1% identity in 504 aa overlap. The N-terminus is similar to several proposed membrane proteins e.g. Streptomyces coelicolor TR:O69916 (EMBL:AL023861) (589 aa), Fasta scores: E(): 0, 47.8% identity in 510 aa overlap. Also similar to ML0233 from M. leprae. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00152 tRNA-synt_2, tRNA synthetases class II (D, K and N). Contains PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1671927 | 1675046 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1393c|lysX
VLALLAAALTTRKRIAWLLLLGNMVLAAVLNAVDMAANGNTPAETFGENLGFAVHVVAILLLVLSYREFWAKVRRGALFKAAAVLVAGDVIGILLSLGLVELFPGSLARQDRLPYVANRVVGFALADPDLFSGKPHVLLNAIFGLFGALALIMATIVLFQSQRADNALTGEDESAIRGLLELYGKNDSLGYFATRRDKSVIFAHNGRAAITYRVEIGVCLASGDPVGDPGAWPQAVDAWLELCQTYGWAPGVMGASSQGAQVFRRAGFNAIELGDEAILRTAVYKLSGPDMRGVRQAVTRARRAGLTVRIRRHSDISANEMADTIARADAWRDTEFERGFSMALGRLGDPADSDCLLVEAVDRDDHVVAILSLVPWGTTGVSLDVMRRSPQSPNGTIELMVSELALKGETLGIARISLNFTMFRAAFEQGAQLGAGPIARLWRGLLLFFSRWWQLETLYRSNIKYLPDWVPRYACYEDARLIPRVGVASVIAEGFLVLPFSRRGRVHTGHHPAVPARLAESGLLHHDGSTPDVSGLQTADVDLEVANSRIPEQVRVRLAKLKTLQLNGIDAYPVGHPPSHTVAQALDADDEGTVSISGRILRIRDYGGVLFAHVRDWSGEIQVLLDNLVLECCCIADFTAAIDLGDIVEMTGNMGFSKNGTRSLIVRNWRLIGKCLRPLPNKWKGLTDPEARVRTRYVDLAVNTESRNLIMARSCVLRSVREMLFAKGFVEVETPILQQIHGGATARPFATRINTYDMDLFLRIAPELYLKRLCIGGVERVFELGRAFRNEGVDFSHNPEFTLLEAYQAHADYLMWIDGCRELIQNAAEAANGTQTLMRPRIEGASGTANHLEPIDISGVWPVKTVYEAVSEALGECVDTSTELATLRKLSDAAHIPYWPHWDTGAVVLKLYEHLVENRTDQPTFYIDFPTSVSPLTRPHRSKPGVAERWDLVAWGIELGTAYSELTDPVEQRRRLHEQSLLAVGGNPEAMELDEDFLQAMEYAMPPTGGLGMGIDRLVMLITGRSIRETLPFPLAKPH
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