Gene ML1406 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameargC
Gene length1044 bp
IdentifierML1406
Location 1687676 bp
Protein summary information
Molecular mass36031.2 Da
Isoelectric point6.59
Protein length348 amino acids
Structural information
PFAMPF01118, PF02774
Orthologs
M. tuberculosis H37RvRv1652
M. lepromatosis Mx1-22AMLPM_1406
Cross-references
UniProtQ9CC15
Gene OntologyNad binding, Arginine biosynthetic process, Cytoplasm, Oxidation-reduction process, Protein dimerization activity, N-acetyl-gamma-glutamyl-phosphate reductase activity
Enzyme Classification1.2.1.38
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE N-ACETL-GAMMA-GLUTAMYL-PHOSHATE REDUCTASE ARGC
CommentsML1406, len: 347 aa. Probable argC, N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38). Highly similar to many N-acetyl-gamma-glutamyl-phosphate reductases involved in arginine biosynthesis, including: Streptomyces coelicolor SW:ARGC_STRCO (AL031541) (342 aa), Fasta scores: E(): 0, 62.1% identity in 346 aa overlap and Mycobacterium tuberculosis Rv1652 SW:ARGC_MYCTU (P94987) (352 aa), Fasta scores: E(): 0, 81.1% identity in 344 aa overlap. Contains Pfam match to entry PF01118 Semialdhyde_dh, Semialdehyde dehydrogenase. Contains PS01224 N-acetyl-gamma-glutamyl-phosphate reductase active site.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS16876761688719+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1406|argC
MSYAIRVAVVGASGYAGGEILRLLLGHPAYADDRLTIGTLTAAASSGDTLGEHHPHLTPLAHRVLESTELTVLAGHDVVFLGLPHGHSAALAERLGPETLIIDCGADFRLTDAGAWGRFYESPYAGSWPYGLPELPGGRERLQKARRIAVPGCYPTAILLALLPAMAEGLIEPAVTVFAVSGISGAGRAAKTKLLGSEVIGSARAYNIGGTHRHTAEIIQGLRVVTDRAVTVSFTPVLIPTSRGILAACTARTSSSLSKLRTAYEKAYQVEPFVYLMPEGQLPFTGAVIGSNAAHIAVAVDEAAETFIAISAIDNLVKGTAGAAVQSMNLALGWPEAEGLSVVGVAP
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