Gene ML1410 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameargF
Gene length921 bp
IdentifierML1410
Location 1692181 bp
Protein summary information
Molecular mass32753.9 Da
Isoelectric point5.15
Protein length307 amino acids
Structural information
PFAMPF00185, PF02729
Orthologs
M. tuberculosis H37RvRv1656
M. lepromatosis Mx1-22AMLPM_1410
Cross-references
UniProtQ9CC11
Gene OntologyArginine biosynthetic process, Ornithine carbamoyltransferase activity, Ornithine carbamoyltransferase complex, Amino acid binding
Enzyme Classification2.1.3.3
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable Ornithine carbamoyltransferase, anabolic ArgF
CommentsML1410, len: 306 aa. Probable argF, Ornithine carbamoyltransferase (EC 2.1.3.3). Highly similar to many ornithine carbamoyltransferase involved in arginine biosynthesis, including: Bacillus subtilis SW:OTCA_BACSU (P18186) (319 aa), Fasta scores: E(): 0, 48.0% identity in 304 aa overlap and Mycobacterium tuberculosis Rv1656 SW:OTCA_MYCTU (P94991) (307 aa), Fasta scores: E(): 0, 85.0% identity in 306 aa overlap. Start changed, was originally 15 codons upstream. Contains Pfam match to entry PF00185 OTCace, Aspartate/ornithine carbamoyltransferase. Contains PS00097 Aspartate and ornithine carbamoyltransferases signature.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS16921811693101+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1410|argF
LTRHFLRDDDLSPTEQADILALAADLKKAPFSRRPLAGPRGVAVIFDKNSTRTRFSFDIGIAQLGGHAVVVDGLSTQLGRDETLQDTARVLSGYVDAIVWRTFGQHRLDAMAATATVPVVNALSDEFHPCQVLADLQTIAERKGSLNGLRLSYFGDGANNMAHSLMLGAVTAGVHVTVATPVGFTPDPSVLAAAKKRAEATGASVTVTVDADTAAAGADVLVTDTWTSMGQENDGLDRVKPFWPFQVNARLVGLADSEAIVLHCLPAHRGDEITNEVMDGPTSAIWDEAENRLHAQKALLVWLLER
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