Gene ML1412 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameargG
Gene length1200 bp
IdentifierML1412
Location 1693617 bp
Protein summary information
Molecular mass43897.6 Da
Isoelectric point5.08
Protein length400 amino acids
Structural information
PFAMPF00764
Orthologs
M. tuberculosis H37RvRv1658
M. lepromatosis Mx1-22AMLPM_1412
Cross-references
UniProtQ9CC10
Gene OntologyArginine biosynthetic process, Argininosuccinate synthase activity, Cytoplasm, Atp binding
Enzyme Classification6.3.4.5
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable Argininosuccinate synthase ArgG (Citrulline--aspartate ligase)
CommentsML1412, len: 399 aa. Probable argG, Argininosuccinate synthase (EC 6.3.4.5). Highly similar to many argininosuccinate synthases involved in arginine biosynthesis, including: Streptomyces clavuligerus SW:ASSY_STRCL (P50986) (397 aa), Fasta scores: E(): 0, 67.0% identity in 397 aa overlap and Mycobacterium tuberculosis Rv1658 SW:ASSY_MYCTU (P94993) (398 aa), Fasta scores: E(): 0, 91.0% identity in 398 aa overlap. Contains Pfam match to entry PF00764 Arginosuc_synth, Arginosuccinate synthase. Contains PS00564 Argininosuccinate synthase signature 1. Contains PS00565 Argininosuccinate synthase signature 2. Belongs to the argininosuccinate synthase family. Subfamily 1
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS16936171694816+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1412|argG
LMPERIILAYSGGLDTSVAINWIGKETSHEVVAVVIDLGQGGEDMEVVRQRALDCGAVEAIVVDARDEFAEGYCLPTVLNNALYMDRYPLVSAISRPLIVKHLVAAARAHGGSIVAHGCTGKGNDQVRFEVGFASLAPDLEILAPVRDYAWTREKAIAFAEENAIPINVTKRSPFSIDQNVWGRAVETGFLEHLWHAPTKEVYSYTDDPTINWNTPDEVIVGFEHGVPVSIDGSPVSMLGAIEALNRRAGAQGVGRLDVVEDRLVGIKSREIYEAPGAMVLITAHAELEHVTLERELGRFKRQTDRRWAELVYDGLWYSPLKTALESFVAATQQHVTGEVRMVLHGGHIAVNGRRSAESLYDFNLATYDEGDTFDQSAARGFVYVYGLPSKLAARRDLR
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