Gene ML1413 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameargH
Gene length1413 bp
IdentifierML1413
Location 1694888 bp
Protein summary information
Molecular mass49936.5 Da
Isoelectric point5.45
Protein length471 amino acids
Structural information
PFAMPF00206
Orthologs
M. tuberculosis H37RvRv1659
M. lepromatosis Mx1-22AMLPM_1413
Cross-references
UniProtQ9CC09
Gene OntologyArgininosuccinate lyase activity, Cytoplasm, Arginine biosynthetic process via ornithine
Enzyme Classification4.3.2.1
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable Argininosuccinate lyase ArgH
CommentsML1413, len: 470 aa. Probable argH, Argininosuccinate lyase (EC 4.3.2.1). Highly similar to many argininosuccinate lyases involved in arginine biosynthesis, including: Escherichia coli SW:ARLY_ECOLI (P11447) (172 aa), BlastP Expect 9.3 and Mycobacterium tuberculosis SW:ARLY_MYCTU (P94994) (470 aa), Fasta scores: E(): 0, 88.1% identity in 470 aa overlap. Contains Pfam match to entry PF00206 lyase_1, Lyase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00163 Fumarate lyases signature.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS16948881696300+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1413|argH
MSTNQGSLWGGRFAAGPSEALVALSKSTHFDWVLAPYDITASRAHTKMLFRAGLLNEEQRDGLLAGLDNLAEDVADGSFLPLVTDEDVHAALERGLIDRVGPDLGGRLRAGRSRNDQVATLFRMWLRDAVRRVAAGALEVVDALANQAAEHSSTIMPGKTHLQSAQPILLAHHLLAHAHPLLRDVGRIVDFDKRAAVSPYGSGALAGSSLGLDPDAMAQDLGFPAAADNSVDATAARDFAAEAAFVFAMIAVDLSRLAEDIILWSSTEFGYARLHDSWSTGSSIMPQKKNPDIAELARGKSGRLIGNLAGLLATLKAQPLAYNRDLQEDKEPVFDSVAQLELLLPAMAGLVASLTFNVERMAALAPAGYTLATDIAEWLVRQGVPFRSAHEAAGTAVRVAEGRGVGLEELTDDELAAISANLTPQVREVLTVEGSVSSRAARGGTAPSQAAKQLTVVRANANQLRQLLMR
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