Gene ML1440c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Polyprenol-monophosphomannose synthase Ppm1a |
| Comments | ML1440c, len: 277 aa. Probable ppm1a, Polyprenol-monophosphomannose synthase. Highly similar to C-terminus of a Polyprenol-monophosphomannose synthase from Mycobacterium tuberculosis Rv2051c TR:O53493 (EMBL:AL021899) (874 aa), Fasta scores: E(): 0, 78.9% identity in 275 aa overlap. Homology to Rv2051c continues downstream of this ORF in a different frame suggesting a possible frameshift. Also similar to other glycosyl transferases e.g. Q827K1 Putative glycosyl transferase from Streptomyces avermitilis (265 aa), fasta scores: E(): 1.3e-57, (56.274% identity in 263 aa overlap). Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases. |
| Functional category | Cell wall and cell processes |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1733643 | 1734476 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1440c|ppm1a
MITGQPARKISGNRPSQCVLVIIPTFNELENLPVTHGRLKDAYPEIHVLIVDDGSPDGTGELADELAQVDPGCTHVMHRTTKDGLGTAYLAGFAWGMSRDYSVLVEMDADGSHAPEQLHRLLGAVDAGADLAIGSRYVNGGTVRNWPWQRLALSKTANKYSRLALGIDVHDITAGYRAYRREVLEAIDLDSVASKGYCFQIDLTWRTVNNGFVIIEVPITFTEREFGLSKMSGSNIREALVKVTRWGIDGRIQRARTGRAYNSVSRGGGTGSSPSAP
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