Gene ML1441c (ppm1) in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameppm1b
Gene length1935 bp
IdentifierML1441c
Location 1734473 bp
Protein summary information
Molecular mass68988.2 Da
Isoelectric point9.66
Protein length645 amino acids
Structural information
PFAMPF00795
Orthologs
M. tuberculosis H37RvRv2051c
M. lepromatosis Mx1-22AMLPM_1441
Cross-references
UniProtQ7AQ49
Gene OntologyHydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, Integral to membrane, Lipoprotein biosynthetic process, Nitrogen compound metabolic process, Plasma membrane, N-acyltransferase activity
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPolyprenol-monophosphomannose synthase Ppm1b
CommentsML1441c, len: 644 aa. Probable ppm1b, Polyprenol-monophosphomannose synthase. Highly similar to the N-terminus of a Polyprenol-monophosphomannose synthase from Mycobacterium tuberculosis Rv2051c TR:O53493 (EMBL:AL021899) (874 aa), Fasta scores: E(): 0, 67.7% identity in 601 aa overlap. Homology to Rv2051c continues downstream of this ORF in a different frame suggesting a possible frameshift. Also similar to several apolipoprotein N-acyltransferases (EC 2.3.1.-) involved in lipoprotein biosynthesis e.g. Rhizobium meliloti SW:LNT_RHIME (Q52910) (541 aa), Fasta scores: E(): 1.3e-08, 26.0% identity in 515 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00795 CN_hydrolase, Carbon-nitrogen hydrolase.
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS17344731736407-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1441c|ppm1b
MVDEIIEIDPVDDDPVNGAFATLAVPSRVVKLRATVCHALAQMGVATVARVPATWAMLVPRLPRLVVAVVAGLLFCASFPSLNWWWAAVVAFALLAWVLTHPTTTPVGGLGYGFLFGLAFYLPLLSWISSLVGATPWWALATAAAFLPGFFGLLAVVVGPLPGWPIWFAVVWAAQEWLKSVVPFGGFPWGSVAFGQADGPLLPLAQLGGAPLLSMAIVLVGCSTTAIALEVVKWWRSSGQSNRSDPPPAVVLPGVCVCLVLLAVVVVWPQVRHAGAGSGGEPVITVAAVQGNVPRLGLDFNAQRRAVLDNHVHETLRLAEDVRAGIVPQPQFVIWPENASDIDPLVNGDAGQEITVAAATIDAPILVGTVLDVQGPVPQAPEYTNTVIVWNPGTGPADRHDKEIVQPFGEYLPMPWLFKRLSKYADRVSHIVPRQSQSSGVVRIAGVPIGVTTCWEVIFDRAARKAVLNGAQLLAAPTNNATFNKTMSEQQLAFAKVRAVEHDRYVVVTGTTGISSVIAPDGSELVRTDFFVPAYLDMQVRLKAKLTPATCWGLTLQWILVGTAGAIVLAAMRHNNGSRSRIVLGLGSSASLKTRVRQANVREALTLRLGDRPLIHLSRLVTTLRSIYKGGQKPRYFGRHKGAK
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