Gene ML1458c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameproA
Gene length1230 bp
IdentifierML1458c
Location 1751755 bp
Protein summary information
Molecular mass42794.5 Da
Isoelectric point5.92
Protein length410 amino acids
Structural information
PFAMPF00171
Orthologues
M. tuberculosisRv2427c
Cross-references
UniProtQ9CBZ7
Gene OntologyCytoplasm, Glutamate-5-semialdehyde dehydrogenase activity, Oxidation-reduction process, Proline biosynthetic process, Nadp binding
Enzyme Classification1.2.1.41
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionINVOLVED IN PROLINE BIOSYNTHESIS PATHWAY (AT THE SECOND STEP). CATALYZES THE NADPH DEPENDENT REDUCTION OF L-GAMMA- GLUTAMYL 5-PHOSPHATE INTO L-GLUTAMATE 5-SEMIALDEHYDE AND PHOSPHATE. THE PRODUCT SPONTANEOUSLY UNDERGOES CYCLIZATION TO FORM 1-PYRROLINE-5-CARBOXYLATE. [CATALYTIC ACTIVITY: L-GLUTAMATE 5-SEMIALDEHYDE + PHOSPHATE + NADP(+) = L-GAMMA-GLUTAMYL 5-PHOSPHATE + NADPH].
ProductPROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDEHYDE DEHYDROGENASE)
CommentsML1458c, len: 409 aa. Probable proA, gamma-glutamyl phosphate reductase protein (EC 1.2.1.41). Highly similar to many gamma-glutamyl phosphate reductases involved in proline biosynthesis, e.g. Bacillus subtilis SW:PROA_BACSU (P39821) (415 aa), Fasta scores: E(): 0, 47.3% identity in 412 aa overlap and Mycobacterium tuberculosis Rv2427c SW:PROA_MYCTU (P71921) (415 aa), Fasta scores: E(): 0, 82.2% identity in 409 aa overlap. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family. Contains PS01223 Gamma-glutamyl phosphate reductase signature. BELONGS TO THE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE FAMILY.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS17517551752984-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1458c|proA
LRQEVHDAARRARVAARALAVMPTVAKDHALRAAATAVTAHTEEILAANAEDLQAARATDTLAATLDRLALDRQRIDQIAGGLRQVAALPDPIGEVLRGYTLPNGLQLRQQRVPLGVVGMIYEGRPNITVDAFGLAFKSGNAALLRGSSSAAKSNQALVEVLHAALVSEDLPADAVQLLSAADRSTVTHLIQARGLVDVVIPRGGANLIDAVVRDAQVPIIETGVGNCHVYVHQAADLEVAERILLNSKTRRPSVCNAAETLLIDAAIADHTMPRLVAALQGAGVTVHGGLSGDPDKADLCREYLSMDIAVAVVDGVDAAIAHINEYGTGHTEAIVTTNMAAAQRFADGVDSATVMVNASTAFTDGGQFGFGAEIGISTQKLHARGPMGLSEMTSTKWIVWGDGQIRPA
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