Gene ML1463c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namenadE
Gene length2043 bp
IdentifierML1463c
Location 1759309 bp
Protein summary information
Molecular mass75542.6 Da
Isoelectric point5.43
Protein length681 amino acids
Structural information
PFAMPF00795, PF02540
Orthologs
M. tuberculosis H37RvRv2438c
M. lepromatosis Mx1-22AMLPM_1463
Cross-references
UniProtQ9CBZ6
Gene OntologyNad biosynthetic process, Nad+ synthase (glutamine-hydrolyzing) activity, Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, Nitrogen compound metabolic process, Atp binding
Enzyme Classification6.3.5.1
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE NADE (NAD(+) SYNTHASE [GLUTAMINE-HYDROLYSING])
CommentsML1463c, len: 680 aa. Probable nadE, glutamine-dependent NAD(+) synthetase (EC 6.3.5.1). Highly similar to several e.g. Rhodobacter capsulatus SW:NADE_RHOCA (Q03638) (552 aa), Fasta scores: E(): 3.6e-11, 24.9% identity in 579 aa overlap glutamine-dependent NAD(+) synthetase and Mycobacterium tuberculosis Rv2438c TR:P71911 (EMBL:Z81451) (679 aa), Fasta scores: E(): 0, 84.4% identity in 679 aa overlap. Contains Pfam match to entry PF00795 CN_hydrolase, Carbon-nitrogen hydrolase. Contains PS00591 Glycosyl hydrolases family 10 active site. BELONGS TO THE NAD SYNTHETASE FAMILY IN THE C-TERMINAL SECTION.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS17593091761351-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1463c|nadE
MDFYNSYSQGFVRVAACTHHASIGDPTTNAASVLRLARQCHDDGVAVAVFPELTLSGYSIEDILLQDLLLEAVEDTVLDIVVASADLLPVLVIGAPLRYRHRIYNTAVIIHRGVVLGVAPKSYLPTYREFYERRQLAPGDDEHGTIGIGDLRAPFGPDLLFAAADLLGLVLHVEICEDMFVPVPPSAEAALAGATVLANLSGSPITIGRAEDRRLLARSASLRCLAAYVYAAAGEGESTTDLAWDGQTMIWENGVLLAESERFPKGEHRSVADVDTELLRSERLRMGTFNDNRRRHRALVEPFRRIEFRLEPPVGNIGLLREVERFPFVPADPQRLQQDCYEAYNIQVSGLEQRLRALDYPKVVIGVSGGLDSTHALIVAARAMDREGRPRSDILAFTLPGFVTGDRTKSNATELCRALGVTFTEIDIRDTATLMLKKIGHPFSRGEVSYDVTFENVQAGVRTDYLFRLANQHGGIVLGTGDLSELGLGWSTYGVGDQMSHYNINAGVPKTLVQHLIRWVIASSQFEEQVDKVLQSVLDTEITPELIPSDGEEKLQSTEAKVGPFALQDFSLFQVLRYGFRPSKIAFLTWHAWSDPNCGKWPPGFPEDKRLSYSLKEIRHWLQIFVQRFYSFSQFKRSALPNGPKVSHGGALSPRGDWRAPSDMSARIWLDEIEREVPEE
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