Gene ML1464c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN PROLINE BIOSYNTHESIS PATHWAY (AT THE FIRST STEP). CATALYZES THE TRANSFER OF A PHOSPHATE GROUP TO GLUTAMATE TO FORM GLUTAMATE 5-PHOSPHATE WHICH RAPIDLY CYCLIZES TO 5-OXOPROLINE [CATALYTIC ACTIVITY: ATP + L-GLUTAMATE = ADP + L-GLUTAMATE 5- PHOSPHATE]. |
| Product | PROBABLE GLUTAMATE 5-KINASE PROTEIN PROB (GAMMA-GLUTAMYL KINASE) (GK) |
| Comments | ML1464c, len: 367 aa.Probable proB, glutamate 5-kinase protein (GK) (EC 2.7.2.11). Highly similar to many glutamate 5-kinases involved in proline biosynthesis e.g. Escherichia coli SW:PROB_ECOLI (P07005) (367 aa), Fasta scores: E(): 0, 39.3% identity in 364 aa overlap and Mycobacterium tuberculosis Rv2439c SW:PROB_MYCTU (P71910) (376 aa), Fasta scores: E(): 0, 84.4% identity in 366 aa overlap. Contains Pfam match to entry PF00696 aakinase, Amino acid kinase family. Contains Pfam match to entry PF01472 PUA, PUA domain. Contains PS00902 Glutamate 5-kinase signature. BELONGS TO THE GLUTAMATE 5-KINASE FAMILY. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1761568 | 1762671 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1464c|proB
VSVHRDAIRAARSLVVKVGTNALTTSSGVFDSSRLARLVDAIEARMKAGTDVVIVSSGAIAAGIEPLGLSLRPKDLATKQAAASVGQVALVNSWSAAFARYGRAVGQVLLTAQDISMRVQHTNAQRTLDRLRALHAVAIVNENDTVATNEIRFGDNDRLSAVVAHLVGAEALVLLSDINGLYDSDPRKNTGARFVPEVTGSADLDGVVASRGSSLGTGGMVSKMSSALLAADAGVPVLLAAAADAATALTDASVGTVFAARPDRMSARRFWLRYAADSVGSLTLDEGAVWAVVQQRRSLLAAGITAVSGRFYGGDVVELRGPDATMVARGVVAYDATELAAMMGRSTSELPCELRRPAVHADDLVSI
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