Gene ML1471c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | CONVERSION OF FOLATES TO POLYGLUTAMATE DERIVATIVES. BACTERIA REQUIRE FOLATE FOR THE BIOSYNTHESIS OF GLYCINE, METHIONINE, FORMYL-MET-TRNA, THYMIDYLATES, PURINES, AND PANTOTHENATE [CATALYTIC ACTIVITY: ATP + {TETRAHYDROFOLYL-[GLU]}(N) + L-GLUTAMATE = ADP + PHOSPHATE + {TETRAHYDROFOLYL-[GLU]}(N+1)]. |
| Product | PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) |
| Comments | ML1471c, len: 485 aa. Probable folC, folylpolyglutamate synthase (EC 6.3.2.17). Highly similar to many folylpolyglutamate synthases including: Lactobacillus casei SW:FOLC_LACCA (P15925) (428 aa), Fasta scores: E(): 0, 34.1% identity in 437 aa overlap and Mycobacterium tuberculosis Rv2447c TR:O53174 (EMBL:AL021246) (487 aa), Fasta scores: E(): 0, 78.7% identity in 483 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family. Contains PS01012 Folylpolyglutamate synthase signature 2. BELONGS TO THE FOLYLPOLYGLUTAMATE SYNTHASE FAMILY. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1768990 | 1770447 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1471c|folC
MTAELPDWGSGRLETNVAALTPDKVASLLQVEHLLDQRWPETCIEPSLTRISALMDVLGSPQLSYPSIHVAGTNGKTSVTRMVDALLTALHQRTGRFTSPHLQSVVERIAIDSKPISPAQYVATYREVEPFVQMIDAQSQSSGGPALSKFEVVTAMAFAAFANAPVDIAVVEVGLGGRWDATNVINASVAVITPVSIDHVEYLGNDVAAIAREKAGIITKAPEGAPDTVVVIGRQVPAAMGVLLAQSAHAGARVVRQDSEFAVLDRQVAIGGQVLQLQGLGGVYNDIYLPLHGEHQAHNAVLVLAAVEAFYGAGVQRQLDVEAVRSGFAAVISPGRLERMRSAPTVFIDAAHNPAGANALARTLSDEFNFRTLVGVLSVLANKDVDGILAALELVLDYIVVTDNGSPRALDVESLALVARERFGPDRVISAANLRDAIDAATALVDDAAANEEIEGLGVSGRGIVITGSVITAGIARTLFGRDPQ
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