Gene ML1472c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namevalS
Gene length2661 bp
IdentifierML1472c
Location 1770444 bp
Protein summary information
Molecular mass98882.3 Da
Isoelectric point4.99
Protein length887 amino acids
Structural information
PFAMPF00133, PF08264, PF10458
Orthologs
M. tuberculosis H37RvRv2448c
M. lepromatosis Mx1-22AMLPM_1472
Cross-references
UniProtQ9CBY7
Gene OntologyCytoplasm, Valine-trna ligase activity, Valyl-trna aminoacylation, Atp binding
Enzyme Classification6.1.1.9
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE VALYL-tRNA SYNTHASE PROTEIN VALS (VALYL-tRNA SYNTHETASE) (VALINE--tRNA LIGASE) (VALINE TRANSLASE) ELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY.
CommentsML1472c, len: 886 aa. Probable valS, valyl-tRNA synthase (EC 6.1.1.9). Highly similar to many valyl-tRNA synthetases including: Bacillus stearothermophilus SW:SYV_BACST (P11931) (880 aa), Fasta scores: E(): 0, 46.6% identity in 894 aa overlap and Mycobacterium tuberculosis Rv2448c SW:SYV_MYCTU (O53175) (876 aa), Fasta scores: E(): 0, 85.4% identity in 876 aa overlap. Contains Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V). Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS17704441773104-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1472c|valS
VTTSPSSSADLLPKSWDPGAMESVIYQKWLNSGYFAADPASTKPGYSIVLPPPNVTGSLHMGHALEHTMMDALTRRKRMQGYEVLWQPGMDHAGIATQSVVEKQLAINGKIKEDFGRELFVDKVWDWKRESGGAIAGQMRRLGDGVDWSRDRFTMDDGLSRAVRMIFKRLYDAGLIYRAERLVNWSPVLRTALSDIEVIYDEIEGELISFRYGSLDDDEPHIVVATTRVETMLGDTGIAVHPDDKRYQHLVGTTLPHPFIDRELVIVADEHVDPEFGTGAVKVTPAHDPNDFEIGLRHNLPMPNVMDVKAVIVDTGTEFDGMDRFEARIAVREALAVQGRIVEEKRPYRHSVGHSERSGEVIEPRLSLQWWVRVESLAKAAGDAVRNGDTVIHPASMESRWFAWVDDMRDWCISRQLWWGHRIPIWYGPNGEQVCVGPDETPPEGWQQDPDVLDTWFSSALWPFSTLGWPQMTPELEKFYPTSILVTGYDILFFWVARMMMLGTFVGGDDAITLGGCRGPQVPFTDVFLHGLIRDEFGRKMSKSRGNVIDPLAWMDMFGADALRFTLARGSSPGGDLAIGEDHVRASRNFGTKLFNATRYALLNGAALVPLPALTALTDADRWILGRLEQVRAEVDSAFDGYEFSRACEALYHFAWDEFCDWYLELAKAQLADGLTHTTAVLAAALDTLLRLLHPVMPFITETLWQALTQLESLVIATWPEPSGISLDLVAAQRISDMQKLVTEIRRFRSDQGLVDRQKVPARLSGVEDSDLATQVGFVTSLALLTAASNDFRPSALLEVRLGPNKDRAVVVELDTSGTIDVAAERRRMEKDLAAAQKELASTAAKLANADFLAKAPEAVVVKIRDRQRMAKEETDRIIARLAGLQ
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