Gene ML1486 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namepepN
Gene length2589 bp
IdentifierML1486
Location 1788674 bp
Protein summary information
Molecular mass94970.5 Da
Isoelectric point4.49
Protein length863 amino acids
Structural information
PFAMPF01433
Orthologs
M. tuberculosis H37RvRv2467
M. lepromatosis Mx1-22AMLPM_1486
Cross-references
UniProtQ9CBX9
Gene OntologyMetallopeptidase activity, Proteolysis, Zinc ion binding, Aminopeptidase activity
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE AMINOPEPTIDASE N PEPN (LYSYL AMINOPEPTIDASE) (LYS-AP) (ALANINE AMINOPEPTIDASE)
CommentsML1486, len: 862 aa. Probable pepN, aminopeptidase (EC 3.4.11.2). Highly similar to many aminopeptidases including: Streptomyces lividans aminopeptidase N (EC 3.4.11.2) SW:AMPN_STRLI (Q11010) (857 aa), Fasta scores: E(): 0, 51.6% identity in 866 aa overlap and Mycobacterium tuberculosis aminopeptidase Rv2467 TR:O53194 (EMBL:AL021246) (861 aa), Fasta scores: E(): 0, 83.3% identity in 862 aa overlap. Contains Pfam match to entry PF01433 Peptidase_M1, Peptidase family M1. Contains PS00142 Neutral zinc metallopeptidases. BELONGS TO PEPTIDASE FAMILY M1 (ZINC METALLOPROTEASE), ALSO KNOWN AS THE PEPN SUBFAMILY.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS17886741791262+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1486|pepN
VALPNLTRDQAVERSALITVDSYQINLDLTDGPDNAPSDRTFRSITTVVFDALAGADTVIDIAADAVRSATLNDHELDVSEYDESTGIPLPGLADRNVVVVDADCRYSNTGEGLHRFVDPVDDEIYLYSQFETADAKRMFACFDQPDLKATFEVEVTACKNWKVISNSVCINITEGTHTFATTPRMSTYLVALIAGPYAAWYASYRDEHGEIPLGIYCRASLAQFMDAERLFTQTKKGFNFYHKHFGLPYAFGKYDQLFVPEFNAGAMENAGAVTFLEDYVFRSKVTRASYERRTETVLHEMAHMWFGNLVTMTWWDDLWLNESFATFASVLCQSEATEFTEAWTTFATVEKSWAYCQDQLPSTHPIVADIPDLAAVEVNFDGITYAKGASVLKQLVAYVGLEQFLAGLRDYFRKHAFANATFDDLLVALENASGRDLSHWSQQWLKTTGINMLRPDFDVDADGKFTRFSVMQSGAEPGAGETRVHRLAVGIYDNCGEADKLVRVHREELDVEGTETEVPALVGISQGKLILVNDDDLTYCSLRLDAQSLQTALQSIADIAEPLPRTLVWSTAWEMTREAELRARDFVALVSGALHAETEVGVAQRLLLQAQTALGSYADPDWARDYGWPQFADRILELARAAVSGSDHQLAFINTLCSSVLSPRHVQTLAALLNDDPTELGLPGVQVDTDLRWRIVTALATAGTLDANGPQTPWIDAEMQRDPTAAGKRHGAQAAAARPQSDIKDKAFTTVVEDDTLTNAAGRAIIAGIVAPGQGELLKPFTARYFAAIPGVWTRRSSEVAQTVVIGLYPHWDISDVGIAAAEEFLTAPESKVPPALRRLVLEGQAAVKRALRARMFDSAD
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